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Your Vote Counts! XOMA CORPORATION 2022 Annual Meeting Vote by May 17, 2022 11:59 PM ET. For shares held in a Plan, vote by May 16, 2022 11:59 PM ET. XOMA CORPORATION ATTN: THOMAS BURNS 2200 POWELL STREET, SUITE 310 EMERYVILLE, CA 94608 D78290-P69988 You invested in XOMA CORPORATION and it’s time to vote! You have the right to vote on proposals being presented at the Annual Meeting. This is an important notice regarding the availability of proxy materials for the stockholder meeting to be held on May 18, 2022. Get informed before you vote View the Notice and Proxy Statement and Annual Report online OR you can receive a free paper or email copy of the material(s) by requesting prior to May 4, 2022. If you would like to request a copy of the material(s) for this and/or future stockholder meetings, you may (1) visit www.ProxyVote.com, (2) call 1-800-579-1639 or (3) send an email to sendmaterial@proxyvote.com. If sending an email, please include your control number (indicated below) in the subject line. Unless requested, you will not otherwise receive a paper or email copy. PV For complete information and to vote, visit www.ProxyVote.com Control # Smartphone users Point your camera here and vote without entering a control number Vote Virtually at the Meeting* May 18, 2022 9:00 AM PDT Vote Virtually at the Meeting: To vote during the Meeting go to www.virtualshareholdermeeting.com/XOMA2022. Have the control number that is printed in the box available and follow the instructions.Vote Before the Meeting by Internet: To vote now by internet, go to www.proxyvote.com. Have the control number that is printed in the box available and follow the instructions. Vote Before the Meeting by Mail: You can vote by mail by requesting a paper copy of the materials, which will include a proxy card. Vote Before the Meeting by Phone: You can vote by phone by dialing 1-800-690-6903 using any touch-tone telephone. *Please check the meeting materials for any special requirements for meeting attendance. V1


Vote at www.ProxyVote.com THIS IS NOT A VOTABLE BALLOT This is an overview of the proposals being presented at the upcoming stockholder meeting. Please follow the instructions on the reverse side to vote these important matters. Voting Items Board Recommends 1. Election of Directors Nominees: 01) James R. Neal 02) W. Denman Van Ness 03) Joseph M. Limber 04) Jack L. Wyszomierski 05) Matthew D. Perry 06) Barbara Kosacz 07) Natasha Hernday 08) Heather L. Franklin For 2. To approve an amendment to the XOMA Corporation Amended and Restated 2010 Long Term Incentive and Stock Award Plan, to increase the aggregate number of shares of common stock authorized for issuance thereunder by 275,000 shares; and For 3. To ratify the selection by the Audit Committee of the Board of Deloitte & Touche LLP as the independent registered public accounting firm of XOMA for its fiscal year ending December 31, 2022. For NOTE: To transact such other business as may properly come before the annual meeting or any adjournment. Prefer to receive an email instead? While voting on www.ProxyVote.com, be sure to click “Sign up for E-delivery”. D78291-P69988