Quarterly report pursuant to Section 13 or 15(d)

Long-Term Debt - Interest Expense and Amortization of Debt Issuance Costs (Details)

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Long-Term Debt - Interest Expense and Amortization of Debt Issuance Costs (Details) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2017
Sep. 30, 2016
Sep. 30, 2017
Sep. 30, 2016
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense $ 202 $ 982 $ 1,108 $ 2,991
Hercules Term Loan [Member]        
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense   651 311 2,001
Servier Loan [Member]        
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense 76 223 431 674
Novartis Note [Member]        
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense $ 126 104 362 299
Other [Member]        
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense   $ 4 $ 4 $ 17