Quarterly report pursuant to Section 13 or 15(d)

Long-Term Debt - Interest Expense and Amortization of Debt Issuance Costs and Discounts (Details)

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Long-Term Debt - Interest Expense and Amortization of Debt Issuance Costs and Discounts (Details) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2017
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense $ 209 $ 202 $ 557 $ 1,108
Novartis Note [Member]        
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense 171 126 453 362
SVB Loan [Member]        
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense 35   47  
Servier Loan [Member]        
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense   $ 76   431
Hercules Loan [Member]        
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense       311
Other [Member]        
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense $ 3   $ 57 $ 4