Annual report pursuant to Section 13 and 15(d)

CONSOLIDATED STATEMENT OF STOCKHOLDERS' EQUITY

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CONSOLIDATED STATEMENT OF STOCKHOLDERS' EQUITY (USD $)
In Thousands, except Share data, unless otherwise specified
Preferred Shares [Member]
Common Shares [Member]
Paid-In Capital [Member]
Accumulated Comprehensive Income (Loss) [Member]
Accumulated Deficit [Member]
Total
Balance at Dec. 31, 2008 $ 1 $ 70 $ 753,634 $ (2) $ (785,104) $ (31,401)
Balance (in shares) at Dec. 31, 2008 3 9,364        
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Exercise of stock options, contributions to 401(k) and incentive plans 0 1 1,358 0 0 1,359
Exercise of stock options, contributions to 401(k) and incentive plans (in shares)   135        
Stock-based compensation expense 0 0 4,395 0 0 4,395
Sale of shares of common stock 0 30 42,591 0 0 42,621
Sale of shares of common stock (in shares)   4,036        
Comprehensive income (loss):            
Net change in unrealized loss on investments 0 0 0 2 0 2
Net income (loss) 0 0 0 0 550 550
Comprehensive income (loss) 0 0 0 0 0 552
Balance at Dec. 31, 2009 1 101 801,978 0 (784,554) 17,526
Balance (in shares) at Dec. 31, 2009 3 13,536        
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Exercise of stock options, contributions to 401(k) and incentive plans 0 1 945 0 0 946
Exercise of stock options, contributions to 401(k) and incentive plans (in shares)   94        
Stock-based compensation expense 0 0 4,913 0 0 4,913
Sale of shares of common stock 0 109 66,232 0 0 66,341
Sale of shares of common stock (in shares)   14,469        
Exercise of warrants 0 3 2,618 0 0 2,621
Exercise of warrants (in shares)   392        
Comprehensive income (loss):            
Net income (loss) 0 0 0 0 (68,756) (68,756)
Comprehensive income (loss) 0 0 0 0 0 (68,756)
Balance at Dec. 31, 2010 1 214 876,686 0 (853,310) 23,591
Balance (in shares) at Dec. 31, 2010 3 28,491        
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Exercise of stock options, contributions to 401(k) and incentive plans 0 2 1,099 0 0 1,101
Exercise of stock options, contributions to 401(k) and incentive plans (in shares)   253        
Stock-based compensation expense 0 0 7,759 0 0 7,759
Sale of shares of common stock 0 45 15,043 0 0 15,088
Sale of shares of common stock (in shares)   6,108        
Conversion of Series B convertible preferred stock (3) 2 (1) 0 0 0
Conversion of Series B convertible preferred stock (in shares)   255        
Issuance of warrants 0 0 215 0 0 215
Comprehensive income (loss):            
Net income (loss) 0 0 0 0 (32,743) (32,743)
Comprehensive income (loss) 0 0 0 0 0 (32,743)
Balance at Dec. 31, 2011 $ 0 $ 263 $ 900,801 $ 0 $ (886,053) $ 15,011
Balance (in shares) at Dec. 31, 2011   35,107