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Long-Term Debt and Other Financings (Details)
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3 Months Ended | 6 Months Ended | 1 Months Ended | 3 Months Ended | 6 Months Ended | 1 Months Ended | 3 Months Ended | 6 Months Ended | 12 Months Ended | 6 Months Ended | 1 Months Ended | 3 Months Ended | 6 Months Ended | 3 Months Ended | 6 Months Ended | |||||||||||||||||
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Jun. 30, 2014
USD ($)
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Jun. 30, 2013
USD ($)
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Jun. 30, 2014
USD ($)
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Jun. 30, 2013
USD ($)
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Jan. 31, 2014
Novartis Note [Member]
USD ($)
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Jun. 30, 2014
Novartis Note [Member]
USD ($)
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Jun. 30, 2013
Novartis Note [Member]
USD ($)
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Jun. 30, 2014
Novartis Note [Member]
USD ($)
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Jun. 30, 2013
Novartis Note [Member]
USD ($)
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Dec. 31, 2013
Novartis Note [Member]
USD ($)
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Jan. 31, 2014
Servier Loan [Member]
USD ($)
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Jun. 30, 2014
Servier Loan [Member]
USD ($)
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Jun. 30, 2013
Servier Loan [Member]
USD ($)
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Jun. 30, 2014
Servier Loan [Member]
USD ($)
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Jun. 30, 2013
Servier Loan [Member]
USD ($)
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Dec. 31, 2011
Servier Loan [Member]
USD ($)
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Dec. 31, 2013
Servier Loan [Member]
USD ($)
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Dec. 31, 2011
Servier Loan [Member]
EUR (€)
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Jun. 30, 2014
Servier Loan [Member]
Minimum [Member]
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Jun. 30, 2014
Servier Loan [Member]
Maximum [Member]
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Sep. 30, 2012
General Electric Capital Corporation Term Loan [Member]
USD ($)
Installment
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Jun. 30, 2014
General Electric Capital Corporation Term Loan [Member]
USD ($)
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Jun. 30, 2013
General Electric Capital Corporation Term Loan [Member]
USD ($)
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Jun. 30, 2014
General Electric Capital Corporation Term Loan [Member]
USD ($)
Installment
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Jun. 30, 2013
General Electric Capital Corporation Term Loan [Member]
USD ($)
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Dec. 31, 2013
General Electric Capital Corporation Term Loan [Member]
USD ($)
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Sep. 27, 2012
General Electric Capital Corporation Term Loan [Member]
USD ($)
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Dec. 31, 2011
General Electric Capital Corporation Term Loan [Member]
USD ($)
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Jun. 30, 2014
Other Financings [Member]
USD ($)
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Jun. 30, 2013
Other Financings [Member]
USD ($)
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Jun. 30, 2014
Other Financings [Member]
USD ($)
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Jun. 30, 2013
Other Financings [Member]
USD ($)
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| Debt Instrument [Line Items] | ||||||||||||||||||||||||||||||||
| Maturity date | Jun. 30, 2015 | Jun. 15, 2015 | ||||||||||||||||||||||||||||||
| Research and development expenses funded through loan facility, maximum (in hundredths) | 75.00% | |||||||||||||||||||||||||||||||
| Maximum borrowing capacity under loan agreement | $ 50,000,000 | $ 50,000,000 | € 15,000,000 | |||||||||||||||||||||||||||||
| Variable rate basis | six-month LIBOR | Euro Inter-Bank Offered Rate ("EURIBOR") | ||||||||||||||||||||||||||||||
| Basis spread on variable rate (in hundredths) | 2.00% | |||||||||||||||||||||||||||||||
| Interest rate at period end (in hundredths) | 2.27% | 2.27% | ||||||||||||||||||||||||||||||
| Outstanding principal balance | 13,200,000 | 13,200,000 | 14,800,000 | 20,500,000 | 20,500,000 | 20,600,000 | 7,300,000 | 7,300,000 | 9,400,000 | 3,100,000 | 10,000,000 | |||||||||||||||||||||
| Percentage of milestone received (in hundredths) | 25.00% | |||||||||||||||||||||||||||||||
| Milestone received under the collaboration agreement | 7,000,000 | |||||||||||||||||||||||||||||||
| Repayment of debt | 1,750,000 | |||||||||||||||||||||||||||||||
| Proceeds from loan | 19,500,000 | 4,600,000 | ||||||||||||||||||||||||||||||
| Increase (Decrease) in term loan obligation | 12,500,000 | |||||||||||||||||||||||||||||||
| Periodic Payment, Principal | 347,222 | |||||||||||||||||||||||||||||||
| Initial interest rate during period (in hundredths) | 3.22% | |||||||||||||||||||||||||||||||
| Interest rate reset semi-annually during period (in hundredths) | 2.39% | 2.31% | 3.83% | |||||||||||||||||||||||||||||
| Accrued interest | 1,570,000 | (1,757,000) | 1,900,000 | |||||||||||||||||||||||||||||
| Euro to US Dollar exchange rates | 1.3645 | 1.3645 | 1.3766 | |||||||||||||||||||||||||||||
| Interest rate during period (in hundredths) | 2.31% | |||||||||||||||||||||||||||||||
| Unamortized discount on debt | 8,900,000 | 8,900,000 | ||||||||||||||||||||||||||||||
| Unrealized foreign exchange gain (loss) | 241,000 | 265,000 | 200,000 | (300,000) | 200,000 | 300,000 | ||||||||||||||||||||||||||
| Unrealized foreign exchange gain (loss) related to re-measurement of loan discount | (100,000) | 100,000 | (100,000) | (100,000) | ||||||||||||||||||||||||||||
| Amortization period for loan discount | 5 years | |||||||||||||||||||||||||||||||
| Amortization of debt discount | 500,000 | 400,000 | 900,000 | 800,000 | ||||||||||||||||||||||||||||
| Carrying value of the loan | 17,300,000 | 17,300,000 | 16,500,000 | |||||||||||||||||||||||||||||
| Recognition of deferred revenue | 500,000 | 400,000 | 900,000 | 800,000 | ||||||||||||||||||||||||||||
| Debt issuance costs | 200,000 | 1,300,000 | ||||||||||||||||||||||||||||||
| Final payment fee | 500,000 | 500,000 | 875,000 | |||||||||||||||||||||||||||||
| Fixed interest rate accrued (in hundredths) | 11.71% | 11.71% | 10.90% | |||||||||||||||||||||||||||||
| Number of monthly installments | 27 | 42 | ||||||||||||||||||||||||||||||
| Prepayment premium year one (in hundredths) | 3.00% | 3.00% | ||||||||||||||||||||||||||||||
| Prepayment premium year two (in hundredths) | 2.00% | 2.00% | ||||||||||||||||||||||||||||||
| Prepayment premium year thereafter (in hundredths) | 1.00% | 1.00% | ||||||||||||||||||||||||||||||
| Aggregate number of unregistered shares of common stock called by warrants (in shares) | 263,158 | 263,158 | 39,346 | |||||||||||||||||||||||||||||
| Warrants exercise price (in dollars per share) | $ 1.14 | $ 1.14 | $ 3.54 | |||||||||||||||||||||||||||||
| Immediate Term for warrants exercisable (in years) | 5 years | 5 years | ||||||||||||||||||||||||||||||
| Fair value of warrant liability | 200,000 | 200,000 | 100,000 | |||||||||||||||||||||||||||||
| Interest expense and amortization of debt issuance costs [Abstract] | ||||||||||||||||||||||||||||||||
| Interest expense | $ 1,110,000 | $ 1,164,000 | $ 2,236,000 | $ 2,336,000 | $ 78,000 | $ 91,000 | $ 155,000 | $ 182,000 | $ 600,000 | $ 528,000 | $ 1,188,000 | $ 1,053,000 | $ 423,000 | $ 531,000 | $ 870,000 | $ 1,077,000 | $ 9,000 | $ 14,000 | $ 23,000 | $ 24,000 | ||||||||||||