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Long-Term Debt and Other Arrangements (Details)
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12 Months Ended | 6 Months Ended | 12 Months Ended | 1 Months Ended | 12 Months Ended | 12 Months Ended | ||||||||||||||||
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Dec. 31, 2012
USD ($)
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Dec. 31, 2011
USD ($)
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Dec. 31, 2010
USD ($)
|
Dec. 31, 2012
Novartis Note [Member]
USD ($)
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Dec. 31, 2011
Novartis Note [Member]
USD ($)
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Dec. 31, 2010
Novartis Note [Member]
USD ($)
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Jul. 15, 2013
Servier Loan [Member]
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Jan. 15, 2013
Servier Loan [Member]
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Jul. 15, 2012
Servier Loan [Member]
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Jan. 15, 2012
Servier Loan [Member]
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Dec. 31, 2012
Servier Loan [Member]
USD ($)
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Dec. 31, 2011
Servier Loan [Member]
USD ($)
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Dec. 31, 2010
Servier Loan [Member]
USD ($)
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Dec. 31, 2011
Servier Loan [Member]
EUR (€)
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Sep. 30, 2012
General Electric Capital Corporation Term Loan [Member]
USD ($)
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Dec. 31, 2012
General Electric Capital Corporation Term Loan [Member]
USD ($)
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Dec. 31, 2011
General Electric Capital Corporation Term Loan [Member]
USD ($)
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Dec. 31, 2010
General Electric Capital Corporation Term Loan [Member]
USD ($)
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Sep. 27, 2012
General Electric Capital Corporation Term Loan [Member]
USD ($)
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Dec. 31, 2012
Other Financings [Member]
USD ($)
|
Dec. 31, 2011
Other Financings [Member]
USD ($)
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Dec. 31, 2010
Other Financings [Member]
USD ($)
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| Debt Instrument [Line Items] | ||||||||||||||||||||||
| Maturity date | Jun. 30, 2015 | Jun. 15, 2015 | ||||||||||||||||||||
| Research and development expenses funded through loan facility, maximum (in hundredths) | 75.00% | |||||||||||||||||||||
| Maximum borrowing capacity under loan agreement | $ 50,000,000 | € 15,000,000 | ||||||||||||||||||||
| Variable rate basis | six-month LIBOR | Euro Inter-Bank Offered Rate ("EURIBOR") | ||||||||||||||||||||
| Basis spread on variable rate (in hundredths) | 2.00% | |||||||||||||||||||||
| Interest rate at period end (in hundredths) | 2.51% | |||||||||||||||||||||
| Outstanding principal balance | 14,400,000 | 14,000,000 | 19,800,000 | 12,500,000 | 10,000,000 | 3,100,000 | ||||||||||||||||
| Periodic Payment, Principal | 347,222 | |||||||||||||||||||||
| Accrued interest | (1,186,000) | (1,023,000) | (353,000) | 400,000 | 300,000 | 400,000 | ||||||||||||||||
| Proceeds from loan | 19,500,000 | 4,600,000 | ||||||||||||||||||||
| Increase (Decrease) in term loan obligation | 12,500,000 | |||||||||||||||||||||
| Initial interest rate during period (in hundredths) | 3.22% | |||||||||||||||||||||
| Interest rate during period (in hundredths) | 2.33% | 2.80% | 3.54% | 3.83% | ||||||||||||||||||
| Unrealized foreign exchange gain (loss) | (295,000) | (513,000) | 0 | 400,000 | 100,000 | |||||||||||||||||
| Unrealized foreign exchange gains related to re-measurement of loan discount | 100,000 | 600,000 | ||||||||||||||||||||
| Unamortized discount on debt | 8,900,000 | |||||||||||||||||||||
| Amortization period for loan discount | 5 years | |||||||||||||||||||||
| Amortization of debt discount | 1,400,000 | 1,400,000 | ||||||||||||||||||||
| Carrying value of the loan | 14,200,000 | |||||||||||||||||||||
| Recognition of deferred revenue | 1,400,000 | 1,400,000 | ||||||||||||||||||||
| Debt issuance costs | 200,000 | 1,300,000 | ||||||||||||||||||||
| Final payment fee | 500,000 | 875,000 | ||||||||||||||||||||
| Fixed interest rate accrued (in hundredths) | 11.71% | 10.90% | ||||||||||||||||||||
| Number of monthly installments | 27 | 42 | ||||||||||||||||||||
| Prepayment premium year one (in hundredths) | 3.00% | |||||||||||||||||||||
| Prepayment premium year two (in hundredths) | 2.00% | |||||||||||||||||||||
| Prepayment premium year thereafter (in hundredths) | 1.00% | |||||||||||||||||||||
| Aggregate number of unregistered shares of common stock called by warrants (in shares) | 263,158 | 39,346 | ||||||||||||||||||||
| Warrants exercise price (in dollars per share) | $ 1.14 | $ 3.54 | ||||||||||||||||||||
| Immediate Term for warrants exercisable (in years) | 5 years | 5 years | ||||||||||||||||||||
| Fair value of warrant liability | 200,000 | 100,000 | ||||||||||||||||||||
| Aggregate future principal and final fee payments of total interest bearing obligations - long-term [Abstract] | ||||||||||||||||||||||
| 2012 | 3,472,000 | |||||||||||||||||||||
| 2013 | 4,167,000 | |||||||||||||||||||||
| 2014 | 20,167,000 | |||||||||||||||||||||
| 2015 | 19,823,000 | |||||||||||||||||||||
| Long-term debt including current portion | 47,629,000 | |||||||||||||||||||||
| Less current portion | (3,472,000) | |||||||||||||||||||||
| Total long-term debt | 44,157,000 | |||||||||||||||||||||
| Interest expense and amortization of debt issuance costs [Abstract] | ||||||||||||||||||||||
| Interest expense | $ 4,387,000 | $ 2,462,000 | $ 385,000 | $ 397,000 | $ 341,000 | $ 354,000 | $ 2,097,000 | $ 2,087,000 | $ 0 | $ 1,850,000 | $ 0 | $ 0 | $ 43,000 | $ 34,000 | $ 31,000 | |||||||