Income Taxes - Reconciliation between statutory rate and effective rate (Details) |
12 Months Ended | ||
|---|---|---|---|
Dec. 31, 2021 |
Dec. 31, 2020 |
Dec. 31, 2017 |
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| Unrecognized tax benefits activity | |||
| Federal tax at statutory rate | 21.00% | 21.00% | 34.00% |
| Stock compensation and other permanent differences | 9.00% | (6.00%) | |
| Federal orphan drug credit | (2.00%) | ||
| Tax benefit related to CARES Act | (13.00%) | ||
| Tax benefit related to net operating loss carryforward utilization | (11.00%) | ||
| Valuation allowance | (16.00%) | (15.00%) | |
| Total | 1.00% | (13.00%) | |
| X | ||||||||||
- Definition Percentage of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations. Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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- Definition Percentage of domestic federal statutory tax rate applicable to pretax income (loss). Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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| X | ||||||||||
- Definition Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to changes in the valuation allowance for deferred tax assets. Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
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| X | ||||||||||
- Definition A roll forward is a reconciliation of a concept from the beginning of a period to the end of a period. No definition available.
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| X | ||||||||||
- Definition Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to federal orphan drug credit. No definition available.
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| X | ||||||||||
- Definition Percentage of difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying domestic federal statutory income tax rate to pretax income (loss) from continuing operation, attributable to nondeductible expense for share-based payment arrangement and other permanent differences. No definition available.
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| X | ||||||||||
- Definition Percentage of reported income tax expense (benefit) in excess of (less than) expected income tax expense (benefit) computed by applying domestic federal statutory income tax rate to pretax income (loss) from continuing operations, attributable to Tax Benefit Coronavirus Aid, Relief, and Economic Security Act (CARES Act). No definition available.
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| X | ||||||||||
- Definition Percentage of difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying domestic federal statutory income tax rate to pretax income (loss) from continuing operation, attributable to expense (benefit) related to net operating loss carryforward utilization. No definition available.
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