Quarterly report pursuant to Section 13 or 15(d)

Long-Term Debt - Servier Loan Agreement - Additional Information (Details)

v3.8.0.1
Long-Term Debt - Servier Loan Agreement - Additional Information (Details)
1 Months Ended 3 Months Ended 6 Months Ended 9 Months Ended
Aug. 25, 2017
USD ($)
€ / $
Jan. 09, 2015
USD ($)
Tranche
Jan. 31, 2017
USD ($)
Jan. 31, 2016
EUR (€)
Jan. 31, 2011
USD ($)
Sep. 30, 2017
USD ($)
Sep. 30, 2016
USD ($)
Jan. 31, 2018
Jul. 31, 2017
Sep. 30, 2017
USD ($)
Sep. 30, 2016
USD ($)
Sep. 30, 2017
EUR (€)
Jan. 31, 2017
EUR (€)
Dec. 31, 2016
USD ($)
€ / $
Jan. 09, 2015
EUR (€)
Tranche
Debt Instrument [Line Items]                              
Accrued interest paid                   $ 518,000 $ 1,724,000        
Carrying value of the loan           $ 14,300,000       14,300,000          
Loss on extinguishment of debt           135,000       $ 650,000          
Servier Loan [Member]                              
Debt Instrument [Line Items]                              
Date of agreement                   Dec. 30, 2010          
Maximum borrowing capacity under loan agreement | €                       € 15,000,000      
Proceeds from loan         $ 19,500,000                    
Date of loan amendment                   Jan. 09, 2015          
Date of agreement, after amendment                   Aug. 12, 2013          
Number of tranches | Tranche   3                         3
Principal payment amount | €       € 3,000,000                      
Accrued interest paid | €       € 200,000                      
Unamortized discount on debt   $ 1,900,000     $ 8,900,000                    
Amortization of debt discount           200,000 $ 200,000     $ 400,000 500,000        
Carrying value of the loan                           $ 12,200,000  
Unrealized foreign exchange gains (loss) related to re-measurement of loan discount           4,000 6,000     25,000 26,000        
Outstanding principal balance                           $ 12,600,000  
Euro to US Dollar exchange rates | € / $ 1.1932                         1.052  
Unrealized foreign exchange gains (losses) related to re-measurement of loan           (600,000) $ (100,000)     (1,700,000) $ (400,000)        
Payment of debt through cash by NIBR $ 14,300,000                            
Loss on extinguishment of debt           $ 100,000       $ 100,000          
Servier Loan [Member] | Tranche One [Member]                              
Debt Instrument [Line Items]                              
Maturity date   Jan. 15, 2016                          
Principal payment amount | €                             € 3,000,000
Servier Loan [Member] | Tranche Two [Member]                              
Debt Instrument [Line Items]                              
Maturity date   Jan. 15, 2017                          
Principal payment amount | €                             5,000,000
Servier Loan [Member] | Tranche Three [Member]                              
Debt Instrument [Line Items]                              
Maturity date   Jan. 15, 2018                          
Principal payment amount | €                             € 7,000,000
Servier Loan [Member] | Mid-January 2017 Through Mid-July 2017 [Member]                              
Debt Instrument [Line Items]                              
Period of interest resetting                 6 months            
Interest rate during period                 1.77%            
Servier Loan [Member] | Amendment No.3 [Member] | Tranche Two [Member]                              
Debt Instrument [Line Items]                              
Maturity date     Jul. 15, 2017                        
Principal payment amount | €                         € 5,000,000    
Unamortized discount on debt     $ 400,000                        
Servier Loan [Member] | Forecast [Member] | Mid-July 2017 Through Mid-January 2018 [Member]                              
Debt Instrument [Line Items]                              
Period of interest resetting               6 months              
Interest rate during period               1.73%