Quarterly report pursuant to Section 13 or 15(d)

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (unaudited)

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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (unaudited) (USD $)
In Thousands
 9 Months Ended
Sep. 30, 2011
Sep. 30, 2010
Cash flows from operating activities:    
Net loss $ (21,008) $ (50,998)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation 4,052 4,349
Common shares contribution to 401(k) 1,046 905
Share-based compensation expense 5,598 3,743
Accrued interest on interest bearing obligations 762 260
Revaluation of warrant liabilities (3,349) (4,811)
Warrant modification expense 0 4,500
Amortization of discount on long-term debt 1,019 0
Unrealized loss on foreign currency exchange 1,136 0
Unrealized gain on foreign exchange options (157) 0
Other non-cash adjustments 47 19
Changes in assets and liabilities affecting cash:    
Trade and other receivables, net 5,964 (713)
Prepaid expenses and other assets (1,850) (615)
Accounts payable and accrued liabilities (1,305) 2,217
Deferred revenue (13,008) (1,510)
Other liabilities 78 (256)
Net cash used in operating activities (20,975) (42,910)
Cash flows from investing activities:    
Purchase of property and equipment (2,586) (277)
Net cash used in investing activities (2,586) (277)
Cash flows from financing activities:    
Proceeds from issuance of long-term debt 20,102 0
Proceeds from issuance of common shares 12,435 40,638
Payment for modification of warrants 0 (4,500)
Net cash provided by financing activities 32,537 36,138
Effect of exchange rate changes on cash (573) 0
Net increase (decrease) in cash and cash equivalents 8,976 (7,049)
Cash and cash equivalents at the beginning of the period 37,304 23,909
Cash and cash equivalents at the end of the period 45,707 16,860
Supplemental Cash Flow Information:    
Cash paid for income taxes 15 16
Non-cash investing and financing activities:    
Discount on long-term debt (8,899) 0
Issuance and extinguishment of warrant liabilities 0 1,767
Interest added to principal balance on Novartis note 170 164
Interest added to principal balance on Servier loan $ 330 $ 0