Quarterly report pursuant to Section 13 or 15(d)

Long-Term Debt and Other Financings (Details)

v2.4.0.8
Long-Term Debt and Other Financings (Details)
3 Months Ended 1 Months Ended 3 Months Ended 1 Months Ended 3 Months Ended 12 Months Ended 3 Months Ended 1 Months Ended 3 Months Ended 3 Months Ended
Mar. 31, 2014
USD ($)
Mar. 31, 2013
USD ($)
Dec. 31, 2013
USD ($)
Mar. 31, 2012
USD ($)
Jan. 31, 2014
Novartis Note [Member]
USD ($)
Mar. 31, 2014
Novartis Note [Member]
USD ($)
Mar. 31, 2013
Novartis Note [Member]
USD ($)
Dec. 31, 2013
Novartis Note [Member]
USD ($)
Jan. 31, 2014
Servier Loan [Member]
USD ($)
Mar. 31, 2014
Servier Loan [Member]
USD ($)
Mar. 31, 2013
Servier Loan [Member]
USD ($)
Dec. 31, 2011
Servier Loan [Member]
USD ($)
Dec. 31, 2013
Servier Loan [Member]
USD ($)
Dec. 31, 2011
Servier Loan [Member]
EUR (€)
Mar. 31, 2014
Servier Loan [Member]
Minimum [Member]
Mar. 31, 2014
Servier Loan [Member]
Maximum [Member]
Sep. 30, 2012
General Electric Capital Corporation Term Loan [Member]
USD ($)
Installment
Mar. 31, 2014
General Electric Capital Corporation Term Loan [Member]
USD ($)
Installment
Mar. 31, 2013
General Electric Capital Corporation Term Loan [Member]
USD ($)
Sep. 27, 2012
General Electric Capital Corporation Term Loan [Member]
USD ($)
Dec. 31, 2011
General Electric Capital Corporation Term Loan [Member]
USD ($)
Mar. 31, 2014
Other Financings [Member]
USD ($)
Mar. 31, 2013
Other Financings [Member]
USD ($)
Debt Instrument [Line Items]                                              
Maturity date           Jun. 30, 2015                       Jun. 15, 2015          
Research and development expenses funded through loan facility, maximum (in hundredths)           75.00%                                  
Maximum borrowing capacity under loan agreement           $ 50,000,000               € 15,000,000                  
Variable rate basis           six-month LIBOR       Euro Inter-Bank Offered Rate ("EURIBOR")                          
Basis spread on variable rate (in hundredths)           2.00%                                  
Interest rate at period end (in hundredths)           2.35%                                  
Outstanding principal balance     9,400,000     13,000,000   14,800,000   20,600,000               8,300,000   3,100,000 10,000,000    
Percentage of milestone received (in hundredths)         25.00%                                    
Milestone received under the collaboration agreement         7,000,000                                    
Repayment of debt         1,750,000                                    
Periodic Payment, Principal                                 347,222            
Proceeds from loan                       19,500,000         4,600,000            
Increase (Decrease) in term loan obligation                                 12,500,000            
Initial interest rate during period (in hundredths)                   3.22%                          
Interest rate reset semi-annually during period (in hundredths)                   2.39%         2.33% 3.83%              
Accrued interest 1,764,000 (1,586,000)             1,900,000                            
Unamortized discount on debt                   8,900,000                          
Unrealized foreign exchange gain (loss) 66,000 515,000                 600,000                        
Unrealized foreign exchange loss related to re-measurement of loan discount                     200,000                        
Euro to US Dollar exchange rates                   1.3752     1.3766                    
Amortization period for loan discount                   5 years                          
Amortization of debt discount                   500,000 400,000                        
Carrying value of the loan                   17,000,000     16,500,000                    
Recognition of deferred revenue                   500,000 400,000                        
Debt issuance costs                                 200,000 1,300,000          
Final payment fee                                   500,000   875,000      
Fixed interest rate accrued (in hundredths)                                   11.71%   10.90%      
Number of monthly installments                                 27 42          
Prepayment premium year one (in hundredths)                                   3.00%          
Prepayment premium year two (in hundredths)                                   2.00%          
Prepayment premium year thereafter (in hundredths)                                   1.00%          
Aggregate number of unregistered shares of common stock called by warrants (in shares)       14,834,577                           263,158   39,346      
Warrants exercise price (in dollars per share)       $ 1.76                           $ 1.14   $ 3.54      
Immediate Term for warrants exercisable (in years)                                 5 years 5 years          
Fair value of warrant liability                                   200,000   100,000      
Interest expense and amortization of debt issuance costs [Abstract]                                              
Interest expense $ 1,125,000 $ 1,172,000       $ 77,000 $ 91,000     $ 587,000 $ 525,000             $ 448,000 $ 545,000     $ 13,000 $ 11,000