Quarterly report pursuant to Section 13 or 15(d)

Long-Term Debt and Other Financings (Details)

v3.2.0.727
Long-Term Debt and Other Financings (Details)
$ / shares in Units, € in Millions
1 Months Ended 3 Months Ended 6 Months Ended 12 Months Ended
Jan. 09, 2015
EUR (€)
Tranche
Sep. 27, 2012
USD ($)
$ / shares
shares
Jan. 31, 2015
USD ($)
Jun. 30, 2015
USD ($)
$ / shares
shares
Jun. 30, 2014
USD ($)
Jun. 30, 2015
USD ($)
$ / shares
shares
Jun. 30, 2014
USD ($)
Dec. 31, 2011
USD ($)
Feb. 27, 2015
USD ($)
Dec. 31, 2014
USD ($)
Dec. 31, 2011
EUR (€)
Debt Instrument [Line Items]                      
Accrued interest           $ (210,000) $ 1,570,000        
Unrealized foreign exchange gain (loss)           1,571,000 241,000        
Carrying value of the loan       $ 48,004,000   48,004,000          
Loss on extinguishment of debt           (429,000) 0        
Aggregate future principal and final fee payments of total interest bearing obligations - long-term [Abstract]                      
Six months ending December 31, 2015       14,746,000   14,746,000          
Year ended 2016       9,118,000   9,118,000          
Year ended 2017       14,787,000   14,787,000          
Year ended 2018       18,016,000   18,016,000          
Long-term debt including current portion       56,667,000   56,667,000          
Less: Interest, final payment fee, discount and issuance cost       (8,663,000)   (8,663,000)          
Total long-term       48,004,000   48,004,000          
Less: current portion       (15,793,000)   (15,793,000)          
Total long-term debt       32,211,000   32,211,000          
Interest expense and amortization of debt issuance costs [Abstract]                      
Interest expense       1,007,000 $ 1,110,000 $ 2,123,000 2,236,000        
Hercules Loan [Member]                      
Debt Instrument [Line Items]                      
Maturity date           Sep. 01, 2018          
Variable rate basis           The interest rate will be calculated at a rate equal to the greater of either (i) 9.40% plus the prime rate as reported from time to time in The Wall Street Journal minus 7.25%, and (ii) 9.40%.          
Outstanding principal balance       20,000,000   $ 20,000,000          
Unamortized discount on debt       0   0          
Amortization of debt discount       100,000   200,000          
Carrying value of the loan       $ 20,000,000   20,000,000     $ 20,000,000    
Debt issuance costs           $ 500,000          
Aggregate number of unregistered shares of common stock called by warrants (in shares) | shares       181,268   181,268          
Warrants exercise price (in dollars per share) | $ / shares       $ 3.31   $ 3.31          
Fair value of warrant liability                 500,000    
Percentage bearing variable rate (in hundredths)       9.40%   9.40%          
Reduction of percentage of interest under loan agreement (in hundredths)       7.25%   7.25%          
Period of interest           1 year          
Amortization date           Jul. 01, 2016          
Date of extension of amortization           Oct. 01, 2016          
Period of interest amortized           30 months          
Prepayment fee within twelve months of maturity (in hundredths)           3.00%          
Prepayment fee after twelve months but before twenty four months of maturity (in hundredths)           2.00%          
Prepayment fee after twenty four months of maturity (in hundredths)           1.00%          
Additional interest rate in case of default (in hundredths)           5.00%          
Final payment fee       $ 1,200,000   $ 1,200,000          
Exercisable period of warrants           5 years          
Aggregate future principal and final fee payments of total interest bearing obligations - long-term [Abstract]                      
Total long-term       20,000,000   $ 20,000,000     $ 20,000,000    
Interest expense and amortization of debt issuance costs [Abstract]                      
Interest expense       652,000 0 $ 886,000 0        
Servier Loan [Member]                      
Debt Instrument [Line Items]                      
Date of agreement           Dec. 30, 2010          
Date of agreement, after amendment           Aug. 12, 2013          
Maximum borrowing capacity under loan agreement | €                     € 15.0
Period of interest resetting           6 months          
Outstanding principal balance       $ 16,600,000   $ 16,600,000       $ 18,200,000  
Proceeds from loan               $ 19,500,000      
Initial interest rate during period (in hundredths)               3.22%      
Interest rate reset semi-annually during period (in hundredths)           2.16%          
Number of tranches | Tranche 3                    
Accrued interest     $ 200,000                
Euro to US Dollar exchange rates       1.109   1.109       1.216  
Unamortized discount on debt       $ 8,900,000   $ 8,900,000          
Unrealized foreign exchange gain (loss)       (400,000) 200,000 1,600,000 200,000        
Loan discount balance       1,900,000   1,900,000          
Amortization of debt discount       200,000 500,000 300,000 900,000        
Carrying value of the loan       15,200,000   15,200,000       $ 16,200,000  
Unrealized foreign exchange gain (loss) related to re-measurement of loan discount       (35,000) (26,000) 200,000 (32,000)        
Recognition of deferred revenue       200,000 500,000 300,000 900,000        
Debt issuance costs           6,000          
Aggregate future principal and final fee payments of total interest bearing obligations - long-term [Abstract]                      
Total long-term       15,200,000   15,200,000       16,200,000  
Interest expense and amortization of debt issuance costs [Abstract]                      
Interest expense       $ 272,000 600,000 $ 527,000 1,188,000        
Servier Loan [Member] | Minimum [Member]                      
Debt Instrument [Line Items]                      
Interest rate reset semi-annually during period (in hundredths)           2.31%          
Servier Loan [Member] | Maximum [Member]                      
Debt Instrument [Line Items]                      
Interest rate reset semi-annually during period (in hundredths)           3.83%          
Servier Loan [Member] | Tranche One [Member]                      
Debt Instrument [Line Items]                      
Maturity date Jan. 15, 2016                    
Principal payment amount | € € 3.0                    
Servier Loan [Member] | Tranche Two [Member]                      
Debt Instrument [Line Items]                      
Maturity date Jan. 15, 2017                    
Principal payment amount | € € 5.0                    
Servier Loan [Member] | Tranche Three [Member]                      
Debt Instrument [Line Items]                      
Maturity date Jan. 15, 2018                    
Principal payment amount | € € 7.0                    
General Electric Capital Corporation Term Loan [Member]                      
Debt Instrument [Line Items]                      
Outstanding principal balance               $ 10,000,000      
Aggregate number of unregistered shares of common stock called by warrants (in shares) | shares   39,346   263,158   263,158          
Warrants exercise price (in dollars per share) | $ / shares   $ 3.54   $ 1.14   $ 1.14          
Immediate Term for warrants exercisable (in years)   5 years       5 years          
Fair value of warrant liability   $ 100,000           $ 200,000      
Loss on extinguishment of debt           $ 400,000          
Outstanding principle balance and interest           5,500,000          
Interest expense and amortization of debt issuance costs [Abstract]                      
Interest expense       $ 0 423,000 $ 548,000 870,000        
Novartis Note [Member]                      
Debt Instrument [Line Items]                      
Maturity date           Jun. 30, 2015          
Research and development expenses funded through loan facility, maximum (in hundredths)           75.00%          
Maximum borrowing capacity under loan agreement       $ 50,000,000   $ 50,000,000          
Interest rate at period end (in hundredths)       2.44%   2.44%          
Outstanding principal balance       $ 13,500,000   $ 13,500,000       $ 13,400,000  
Interest expense and amortization of debt issuance costs [Abstract]                      
Interest expense       80,000 78,000 $ 159,000 155,000        
Novartis Note [Member] | LIBOR [Member]                      
Debt Instrument [Line Items]                      
Basis spread on variable rate (in hundredths)           2.00%          
Other [Member]                      
Interest expense and amortization of debt issuance costs [Abstract]                      
Interest expense       $ 3,000 $ 9,000 $ 3,000 $ 23,000