Quarterly report pursuant to Section 13 or 15(d)

Fair Value Measurements - Outstanding Debt Carrying Amount and Estimated Fair Value (Details)

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Fair Value Measurements - Outstanding Debt Carrying Amount and Estimated Fair Value (Details) - USD ($)
$ in Thousands
Mar. 31, 2016
Dec. 31, 2015
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]    
Interest-bearing obligations, Carrying amount $ 46,251 $ 48,667
Interest bearing obligations, Estimated Fair value 47,307 49,810
Hercules Term Loan [Member]    
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]    
Interest-bearing obligations, Carrying amount 19,849 19,653
Interest bearing obligations, Estimated Fair value 21,231 21,231
Novartis Note [Member]    
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]    
Interest-bearing obligations, Carrying amount 13,683 13,683
Interest bearing obligations, Estimated Fair value 13,450 13,394
Servier Loan [Member]    
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]    
Interest-bearing obligations, Carrying amount 12,719 15,331
Interest bearing obligations, Estimated Fair value $ 12,626 $ 15,185