Quarterly report pursuant to Section 13 or 15(d)

Stock-based Compensation - Stock-based Compensation Expense (Details)

v3.5.0.2
Stock-based Compensation - Stock-based Compensation Expense (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2016
Jun. 30, 2015
Jun. 30, 2016
Jun. 30, 2015
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]        
Total stock-based compensation expense $ 2,165 $ 2,689 $ 4,471 $ 6,354
Research and Development [Member]        
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]        
Total stock-based compensation expense 857 1,399 1,994 3,595
Selling, General and Administrative [Member]        
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]        
Total stock-based compensation expense $ 1,308 $ 1,290 $ 2,477 $ 2,759