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Long-Term Debt and Other Financings (Details)
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3 Months Ended | 9 Months Ended | 3 Months Ended | 9 Months Ended | 3 Months Ended | 6 Months Ended | 9 Months Ended | 1 Months Ended | 3 Months Ended | 9 Months Ended | 3 Months Ended | 9 Months Ended | 20 Months Ended | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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Sep. 30, 2012
USD ($)
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Sep. 30, 2011
USD ($)
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Sep. 30, 2012
USD ($)
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Sep. 30, 2011
USD ($)
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Sep. 30, 2012
EUR (€)
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Mar. 09, 2012
USD ($)
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Sep. 30, 2012
Novartis Note [Member]
USD ($)
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Sep. 30, 2011
Novartis Note [Member]
USD ($)
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Sep. 30, 2012
Novartis Note [Member]
USD ($)
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Sep. 30, 2011
Novartis Note [Member]
USD ($)
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Dec. 31, 2011
Novartis Note [Member]
USD ($)
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Sep. 30, 2012
Novartis Note [Member]
Maximum [Member]
USD ($)
|
Sep. 30, 2012
Servier Loan [Member]
USD ($)
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Sep. 30, 2011
Servier Loan [Member]
USD ($)
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Jun. 30, 2012
Servier Loan [Member]
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Dec. 31, 2011
Servier Loan [Member]
USD ($)
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Sep. 30, 2012
Servier Loan [Member]
USD ($)
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Sep. 30, 2011
Servier Loan [Member]
USD ($)
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Sep. 30, 2012
General Electric Capital Corporation Term Loan [Member]
USD ($)
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Dec. 31, 2011
General Electric Capital Corporation Term Loan [Member]
USD ($)
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Sep. 30, 2012
General Electric Capital Corporation Term Loan [Member]
USD ($)
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Sep. 30, 2011
General Electric Capital Corporation Term Loan [Member]
USD ($)
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Sep. 30, 2012
General Electric Capital Corporation Term Loan [Member]
USD ($)
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Sep. 30, 2011
General Electric Capital Corporation Term Loan [Member]
USD ($)
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Sep. 30, 2012
Other Financings [Member]
USD ($)
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Sep. 30, 2011
Other Financings [Member]
USD ($)
|
Sep. 30, 2012
Other Financings [Member]
USD ($)
|
Sep. 30, 2011
Other Financings [Member]
USD ($)
|
Sep. 30, 2012
Other Financings [Member]
USD ($)
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| Novartis Note [Abstract] | |||||||||||||||||||||||||||||
| Maturity date | Jun. 30, 2015 | Jun. 15, 2015 | |||||||||||||||||||||||||||
| Maximum percentage for semi-annual borrowings (in hundredths) | 75.00% | 75.00% | |||||||||||||||||||||||||||
| Aggregate principal amount | $ 50,000,000 | $ 10,000,000 | |||||||||||||||||||||||||||
| Variable rate basis | six-month LIBOR | EURIBOR | |||||||||||||||||||||||||||
| Basis spread on variable rate (in hundredths) | 2.00% | 2.00% | |||||||||||||||||||||||||||
| Interest rate at period end (in hundredths) | 2.74% | 2.74% | |||||||||||||||||||||||||||
| Outstanding principal balance | 14,200,000 | 14,200,000 | 14,000,000 | 19,300,000 | 19,400,000 | 19,300,000 | |||||||||||||||||||||||
| Servier Loan [Abstract] | |||||||||||||||||||||||||||||
| Maximum borrowing capacity under loan agreement | 15,000,000 | ||||||||||||||||||||||||||||
| Proceeds from loan | 19,500,000 | ||||||||||||||||||||||||||||
| Initial interest rate during period (in hundredths) | 3.22% | ||||||||||||||||||||||||||||
| Interest rate during period (in hundredths) | 2.80% | 3.54% | 3.83% | ||||||||||||||||||||||||||
| Servier loan maturity year | 2016 | ||||||||||||||||||||||||||||
| Recorded unrealized foreign exchange losses (gain) | (88,000) | 1,136,000 | 400,000 | (1,200,000) | (100,000) | 900,000 | |||||||||||||||||||||||
| Unamortized discount on debt | 55,000 | 8,899,000 | 55,000 | 8,899,000 | 8,900,000 | 8,900,000 | |||||||||||||||||||||||
| Amortization period for loan discount | 5 years | ||||||||||||||||||||||||||||
| Amortization of debt discount | 400,000 | 300,000 | 1,100,000 | 1,000,000 | |||||||||||||||||||||||||
| Carrying value of the loan | 13,500,000 | 12,500,000 | 13,500,000 | 12,500,000 | 12,500,000 | 12,500,000 | |||||||||||||||||||||||
| Unrealized foreign exchange loss related to re-measurement of loan discount | 200,000 | 100,000 | 400,000 | ||||||||||||||||||||||||||
| Unrealized foreign exchange gains related to re-measurement of loan discount | 100,000 | ||||||||||||||||||||||||||||
| Recognition of deferred revenue | 400,000 | 300,000 | 1,100,000 | 1,000,000 | |||||||||||||||||||||||||
| General Electric Capital Corporation Term Loan [Abstract] | |||||||||||||||||||||||||||||
| Fixed interest rate accrued (in hundredths) | 11.71% | 11.71% | 11.71% | ||||||||||||||||||||||||||
| Number of monthly installments | 42 | 27 | |||||||||||||||||||||||||||
| Debt issuance costs | 1,300,000 | 200,000 | |||||||||||||||||||||||||||
| Final payment due on maturity | 875,000 | 500,000 | 875,000 | 875,000 | |||||||||||||||||||||||||
| Aggregate number of unregistered shares of common stock (in shares) | 0.5 | 39,346 | 263,158 | 39,346 | 39,346 | ||||||||||||||||||||||||
| Warrants exercise price (in dollars per share) | $ 3.54 | $ 1.14 | $ 3.54 | $ 3.54 | |||||||||||||||||||||||||
| Warrants exercisable expiration date | Dec. 30, 2016 | ||||||||||||||||||||||||||||
| Fair value of warrant liability | 32,100,000 | 32,100,000 | 100,000 | 200,000 | 100,000 | 100,000 | |||||||||||||||||||||||
| Additional Term Loan | 4,600,000 | ||||||||||||||||||||||||||||
| Stated interest rate (in hundredths) | 10.90% | 10.90% | 10.90% | ||||||||||||||||||||||||||
| Periodic monthly principal payment | 347,222 | ||||||||||||||||||||||||||||
| Remaining outstanding principal amount and accrued interest due on maturity date | 3,100,000 | 3,100,000 | 3,100,000 | ||||||||||||||||||||||||||
| Prepayment premium year one (in hundredths) | 3.00% | 3.00% | 3.00% | ||||||||||||||||||||||||||
| Prepayment premium year two (in hundredths) | 2.00% | 2.00% | 2.00% | ||||||||||||||||||||||||||
| Prepayment premium year thereafter (in hundredths) | 1.00% | 1.00% | 1.00% | ||||||||||||||||||||||||||
| Interest expense | 1,144,000 | 652,000 | 3,211,000 | 1,818,000 | 99,000 | 85,000 | 298,000 | 254,000 | 558,000 | 564,000 | 1,583,000 | 1,544,000 | 475,000 | 0 | 1,298,000 | 0 | 12,000 | 3,000 | 32,000 | 20,000 | |||||||||
| ATM Agreement [Abstract] | |||||||||||||||||||||||||||||
| Common stock sold (in shares) | 2,285,375 | 7,572,327 | |||||||||||||||||||||||||||
| Proceeds from issuance of common stock | 39,624,000 | 12,435,000 | 14,600,000 | 3,300,000 | |||||||||||||||||||||||||
| Offering costs | 100,000 | 400,000 | |||||||||||||||||||||||||||
| Underwritten offering and amendment to shareholder rights plan [Abstract] | |||||||||||||||||||||||||||||
| Underwritten public offering shares of common stock (in shares) | 29,669,154 | ||||||||||||||||||||||||||||
| Warrant rights per share of common stock (in shares) | 0.5 | 39,346 | 263,158 | 39,346 | 39,346 | ||||||||||||||||||||||||
| Public offering price (in dollars per share) | $ 1.76 | $ 1.76 | $ 1.32 | ||||||||||||||||||||||||||
| Total gross proceeds from offering | 39,200,000 | ||||||||||||||||||||||||||||
| Underwriting discounts, commissions and estimated offering expenses | $ 3,000,000 | ||||||||||||||||||||||||||||
| Warrants outstanding (in shares) | 14,743,697 | 14,743,697 | 14,834,577 | ||||||||||||||||||||||||||
| Term of warrants | 5 years | 5 years | |||||||||||||||||||||||||||
| Percentage of beneficial ownership (in hundredths) | 20.00% | 20.00% | |||||||||||||||||||||||||||
| Percentage of common stock ownership (in hundredths) | 40.00% | 40.00% | |||||||||||||||||||||||||||
| Number of times the market value of common stock exercise price | 2 | 2 | |||||||||||||||||||||||||||