Quarterly report pursuant to Section 13 or 15(d)

Stock-based Compensation (Details)

v2.4.0.6
Stock-based Compensation (Details) (USD $)
In Thousands, except Share data, unless otherwise specified
3 Months Ended 9 Months Ended
Sep. 30, 2012
Sep. 30, 2011
Sep. 30, 2012
Sep. 30, 2011
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]        
Total stock-based compensation expense $ 2,122 $ 1,542 $ 3,368 $ 5,598
Research and Development [Member]
       
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]        
Total stock-based compensation expense 1,304 458 1,984 2,404
Selling, General and Administrative Expenses [Member]
       
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]        
Total stock-based compensation expense 818 1,084 1,384 3,194
Stock Options [Member]
       
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Number of shares authorized for issuance (in shares) 2,161,920   2,161,920  
Stock-based awards weighted average assumptions [Abstract]        
Dividend yield (in hundredths) 0.00% 0.00% 0.00% 0.00%
Expected volatility (in hundredths) 92.00% 89.00% 92.00% 87.00%
Risk free interest rate (in hundredths) 0.65% 0.96% 0.83% 1.86%
Expected term 5 years 7 months 6 days 5 years 7 months 6 days 5 years 7 months 6 days 5 years 3 months 18 days
Stock option activity [Roll Forward]        
Options outstanding beginning of period (in shares)     5,053,435  
Granted (in shares)     2,161,920  
Exercised (in shares)     (77,797)  
Forfeited, expired or cancelled (in shares)     (484,144)  
Options outstanding end of period (in shares) 6,653,414   6,653,414  
Options exercisable at end period (in shares) 4,003,868   4,003,868  
Stock options activity, weighted average exercise price [Roll Forward]        
Options outstanding, beginning of period (in dollars per share)     $ 12.55  
Granted (in dollars per share)     $ 2.57  
Exercised (in dollars per share)     $ 1.69  
Forfeited, expired or cancelled (in dollars per share)     $ 15.96  
Options outstanding, end of period (in dollars per share) $ 9.19   $ 9.19  
Options exercisable weighted average exercise price (in dollars per share) $ 13.10   $ 13.10  
Additional Disclosures [Abstract]        
Options outstanding weighted average remaining contractual term beginning of period     6 years 10 months 20 days  
Options outstanding weighted average remaining contractual term end of period     6 years 10 months 20 days  
Options exercisable weighted average remaining contractual term     6 years 6 months 11 days  
Options outstanding, aggregate intrinsic value at beginning of period     0  
Options outstanding, aggregate intrinsic value at end of period 4,520,629   4,520,629  
Options exercisable, aggregate intrinsic value $ 2,106,931   $ 2,106,931  
Stock Options [Member] | Directors [Member]
       
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Vesting period     1 year  
Stock Options [Member] | Employees [Member]
       
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Vesting period     4 years  
Restricted Stock Units (RSUs) [Member]
       
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Number of shares authorized for issuance (in shares) 1,190,323   1,190,323  
Vesting period     3 years  
Unvested RSU activity [Roll Forward]        
Unvested balance beginning of period (in shares)     903,874  
Granted (in shares)     1,190,323  
Vested (in shares)     (194,629)  
Forfeited (in shares)     (200,261)  
Unvested balance end of period (in shares) 1,699,307   1,699,307  
Share-based , nonvested, weighted average grant date fair value [Roll Forward]        
Unvested balance beginning of period (in dollars per share)     $ 1.69  
Granted (in dollars per share)     $ 2.84  
Vested (in dollars per share)     $ 3.44  
Forfeited (in dollars per share)     $ 1.69  
Unvested balance end of period (in dollars per share) $ 2.29   $ 2.29