Quarterly report pursuant to Section 13 or 15(d)

Commitments and Contingencies - Additional Information (Details)

v3.19.3
Commitments and Contingencies - Additional Information (Details)
 1 Months Ended 3 Months Ended 9 Months Ended
Sep. 30, 2019
USD ($)
Facility
Subtenant
Apr. 14, 2018
USD ($)
Facility
Nov. 21, 2017
USD ($)
Facility
Sep. 30, 2019
USD ($)
Facility
Subtenant
Jan. 31, 2019
USD ($)
Facility
Oct. 31, 2018
USD ($)
Facility
Sep. 30, 2019
USD ($)
Facility
Subtenant
Sep. 30, 2018
USD ($)
Jun. 30, 2018
USD ($)
Sep. 30, 2019
USD ($)
Facility
Subtenant
Sep. 30, 2018
USD ($)
Jan. 01, 2019
Lease
Dec. 31, 2016
Facility
Commitments And Contingencies [Line Items]                          
Estimate of milestone payments $ 7,600,000     $ 7,600,000     $ 7,600,000     $ 7,600,000      
Payments of contingent consideration             0            
Operating leases, number of leased facilities | Facility   3 3   3 3              
Number of operating leases right of use assets and lease liability recognized | Lease                       3  
Rent expense recognized for operating leases             600,000     1,800,000      
Variable lease payments             400,000     1,300,000      
Operating leases, number of portions of leased facilities | Facility   1 1   1 1              
Operating leases, sublease commencement date   May 01, 2018 Dec. 26, 2017   Jan. 18, 2019 Oct. 24, 2018              
Operating leases sublease income plus reimbursement of operating expenses receivable   $ 1,100,000 $ 5,100,000                    
Operating leases sublease expiry date   2023-04 2023-04   2023-04 2021-05              
Sublease tenant improvement allowance   $ 65,000 $ 800,000   $ 91,000                
Operating leases sublease income receivable         1,700,000 $ 1,700,000              
Sublease Agreement Commenced on December 26, 2017 [Member]                          
Commitments And Contingencies [Line Items]                          
Sublease loss     800,000                    
Sublease income             400,000 $ 400,000   1,100,000 $ 1,100,000    
Sublease Agreement Commenced on December 26, 2017 [Member] | Standby Letter of Credit [Member]                          
Commitments And Contingencies [Line Items]                          
Letter of credit amount     $ 1,000,000                    
Funds drawn from letter of credit $ 0                        
Sublease Agreement Commenced on May 1,2018 [Member]                          
Commitments And Contingencies [Line Items]                          
Sublease income             100,000 $ 100,000   300,000 $ 200,000    
Sublease broker commissions   $ 89,000                      
Sublease Agreement Commenced on May 1,2018 [Member] | Restructuring Charges [Member]                          
Commitments And Contingencies [Line Items]                          
Sublease loss                 $ 600,000        
Sublease Agreement Commenced on October 24,2018 [Member]                          
Commitments And Contingencies [Line Items]                          
Sublease income             200,000     500,000      
Sublease broker commissions           $ 100,000              
Sublease Agreement Commenced on January 18, 2019 [Member]                          
Commitments And Contingencies [Line Items]                          
Sublease income             $ 200,000     $ 400,000      
Sublease broker commissions         $ 53,000                
Berkeley, California [Member]                          
Commitments And Contingencies [Line Items]                          
Operating leases, number of leased facilities | Facility 2     2     2     2     2
Operating leases, number of subtenants | Subtenant 4     4     4     4      
Emeryville, California [Member]                          
Commitments And Contingencies [Line Items]                          
Operating leases, number of leased facilities | Facility 1     1     1     1      
Operating leases, description                   The Emeryville lease contains both an option to early terminate the lease and an option to extend the lease for an additional term, however, the Company is not reasonably assured to exercise either option.      
Operating leases, option to extend, description                   option to extend the lease      
Operating leases, option to extend                   true      
Operating leases, option to terminate, description                   option to early terminate the lease      
Operating leases, option to terminate                   true      
Operating leases, expiry date                   2023-02      
Maximum [Member] | Berkeley, California [Member]                          
Commitments And Contingencies [Line Items]                          
Operating leases, remaining lease term                   4 years      
Minimum [Member] | Berkeley, California [Member]                          
Commitments And Contingencies [Line Items]                          
Operating leases, remaining lease term                   2 years      
Royalty Purchase Agreement [Member] | Aronora [Member]                          
Commitments And Contingencies [Line Items]                          
Contingent consideration liability per product $ 100,000     $ 100,000     $ 100,000     $ 100,000      
Estimated fair value of contingent consideration 3,000,000     3,000,000     3,000,000     3,000,000      
Payments of contingent consideration       3,000,000                  
Royalty Purchase Agreement [Member] | Bioasis Technologies Inc [Member]                          
Commitments And Contingencies [Line Items]                          
Estimated fair value of contingent consideration 100,000     100,000     100,000     100,000      
Royalty Purchase Agreement [Member] | Bioasis Technologies Inc [Member] | Maximum [Member]                          
Commitments And Contingencies [Line Items]                          
Contingent consideration liability 3,000,000     3,000,000     3,000,000     3,000,000      
Royalty Purchase Agreement [Member] | Bioasis Technologies Inc [Member] | Contingent Consideration [Member]                          
Commitments And Contingencies [Line Items]                          
Estimated fair value of contingent consideration $ 100,000     $ 100,000     $ 100,000     $ 100,000