Quarterly report pursuant to Section 13 or 15(d)

Long-Term Debt and Other Financings - Silicon Valley Bank Loan Agreement (Details)

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Long-Term Debt and Other Financings - Silicon Valley Bank Loan Agreement (Details) - USD ($)
$ / shares in Units, $ in Thousands
 1 Months Ended 3 Months Ended 12 Months Ended
Mar. 04, 2019
May 07, 2018
Sep. 30, 2018
Mar. 31, 2020
Mar. 31, 2019
Dec. 31, 2019
May 31, 2018
Long-term debt              
Aggregate number of shares of common stock called by warrants       19,426   28,489  
Debt amount       $ 31,531      
Current portion of long-term debt       6,390   $ 5,184 [1]  
Long-term debt       25,141   27,093 [1]  
Common stock warrant, Exercise price $23.69 per share, Issued May 2018              
Long-term debt              
Aggregate number of shares of common stock called by warrants             6,332
Exercise price of per share (in dollars per share)             $ 23.69
Common stock warrant, Exercise price $14.71 per share, Issued March 2019              
Long-term debt              
Aggregate number of shares of common stock called by warrants         4,845    
Exercise price of per share (in dollars per share)         $ 14.71    
Silicon Valley Bank Loan Agreement              
Long-term debt              
Maximum borrowing capacity under loan agreement   $ 20,000          
Aggregate borrowing capacity consisting of the maximum borrowing capacity plus the contingent increase   40,000          
Cash proceeds to be received from milestone and licensing payments in order to extend draw period   $ 20,000          
Period of monthly payments of principal and interest   24 months          
Maximum period following loan amortization date for which loan will mature   161 days          
Maximum period prior to loan maturity date of Novartis loan for which loan will mature   30 days          
Amount of loan that may be reborrowed after repayment   $ 0          
Final payment fee (as a percent)   8.50%          
Additional interest rate in the event of default (as a percent)   4.00%          
Debt issuance costs   $ 200          
Non-cash interest expense resulting from amortization of discount and accretion of final payment       200 $ 100    
Debt amount       15,600   16,400  
Current portion of long-term debt       6,400   5,200  
Long-term debt       $ 9,200   11,200  
Silicon Valley Bank Loan Agreement | Minimum              
Long-term debt              
Interest rate (as a percent)   4.75%          
Silicon Valley Bank Loan Agreement | Common stock warrant, Exercise price $23.69 per share, Issued May 2018              
Long-term debt              
Aggregate number of shares of common stock called by warrants   6,332          
Exercise price of per share (in dollars per share)   $ 23.69          
Exercisable period of warrants   10 years          
Fair value of warrant   $ 100          
Silicon Valley Bank Loan Agreement | Common stock warrant, Exercise price $14.71 per share, Issued March 2019              
Long-term debt              
Aggregate number of shares of common stock called by warrants 4,845            
Exercise price of per share (in dollars per share) $ 14.71            
Exercisable period of warrants 10 years            
Fair value of warrant $ 100            
Silicon Valley Bank Loan Agreement | Prime Rate              
Long-term debt              
Basis spread on variable rate   0.25%          
Silicon Valley Bank Loan Agreement | On or before first anniversary              
Long-term debt              
Prepayment fee (as a percent)   3.00%          
Silicon Valley Bank Loan Agreement | Following first anniversary              
Long-term debt              
Prepayment fee (as a percent)   2.00%          
Silicon Valley Bank Loan Agreement | Following second anniversary              
Long-term debt              
Prepayment fee (as a percent)   1.00%          
Silicon Valley Bank, First Term Loan              
Long-term debt              
Proceeds from issuance of long-term debt     $ 7,500        
Unamortized discount     $ 300        
Silicon Valley Bank, Second Term Loan              
Long-term debt              
Proceeds from issuance of long-term debt           9,500  
Unamortized discount           $ 45  
[1] The consolidated balance sheet as of December 31, 2019 has been derived from the audited consolidated financial statements as of that date included in the Company’s Annual Report on Form 10K for the year ended December 31, 2019.