Quarterly report pursuant to Section 13 or 15(d)

Long-Term Debt - Interest Expense and Amortization of Debt Issuance Costs (Details)

v3.8.0.1
Long-Term Debt - Interest Expense and Amortization of Debt Issuance Costs (Details) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2018
Mar. 31, 2017
Interest expense and amortization of debt issuance costs [Abstract]    
Interest expense $ 170 $ 609
Novartis Note [Member]    
Interest expense and amortization of debt issuance costs [Abstract]    
Interest expense 139 117
Servier Loan [Member]    
Interest expense and amortization of debt issuance costs [Abstract]    
Interest expense   177
Hercules Loan [Member]    
Interest expense and amortization of debt issuance costs [Abstract]    
Interest expense   311
Other [Member]    
Interest expense and amortization of debt issuance costs [Abstract]    
Interest expense $ 31 $ 4