Consolidated Financial Statement Detail (Details)
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12 Months Ended | 1 Months Ended | 12 Months Ended | 12 Months Ended | 1 Months Ended | 12 Months Ended | 12 Months Ended | ||||||||||||||||||||||||||||
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Dec. 31, 2014
USD ($)
|
Dec. 31, 2013
USD ($)
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Dec. 31, 2012
USD ($)
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Mar. 31, 2012
Five Year Warrants Issued in February 2010 [Member]
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Feb. 28, 2010
Five Year Warrants Issued in February 2010 [Member]
USD ($)
|
Dec. 31, 2014
Five Year Warrants Issued in February 2010 [Member]
USD ($)
|
Dec. 31, 2013
Five Year Warrants Issued in February 2010 [Member]
USD ($)
|
Feb. 28, 2010
Five Year Warrants Issued in February 2010 [Member]
|
Dec. 31, 2014
Five Year Warrants Issued in March 2012 [Member]
USD ($)
|
Dec. 31, 2013
Five Year Warrants Issued in March 2012 [Member]
USD ($)
|
Mar. 31, 2012
Five Year Warrants Issued in March 2012 [Member]
USD ($)
|
Dec. 31, 2014
Two Year Warrants Issued in December 2014 [Member]
USD ($)
|
Dec. 08, 2014
Two Year Warrants Issued in December 2014 [Member]
USD ($)
|
Jun. 30, 2009
Warrants Issued to Private Investors [Member]
USD ($)
|
Dec. 31, 2014
Warrants Issued to Private Investors [Member]
USD ($)
|
Dec. 31, 2013
Warrants Issued to Private Investors [Member]
USD ($)
|
Jun. 30, 2009
Warrants Issued to Private Investors [Member]
|
Dec. 31, 2014
Equipment and Furniture [Member]
USD ($)
|
Dec. 31, 2013
Equipment and Furniture [Member]
USD ($)
|
Dec. 31, 2014
Buildings, Leasehold and Building Improvements [Member]
USD ($)
|
Dec. 31, 2013
Buildings, Leasehold and Building Improvements [Member]
USD ($)
|
Dec. 31, 2014
Construction-in-Progress [Member]
USD ($)
|
Dec. 31, 2013
Construction-in-Progress [Member]
USD ($)
|
Dec. 31, 2014
Land [Member]
USD ($)
|
Dec. 31, 2013
Land [Member]
USD ($)
|
Dec. 31, 2014
Options Contract [Member]
USD ($)
Contract
|
Dec. 31, 2013
Options Contract [Member]
USD ($)
|
Dec. 31, 2012
Options Contract [Member]
USD ($)
|
Dec. 31, 2014
Options Contract [Member]
EUR (€)
|
Dec. 31, 2014
Option Contract 1 [Member]
EUR (€)
|
Dec. 31, 2014
Option Contract 2 [Member]
EUR (€)
|
Dec. 31, 2014
Demand Deposits [Member]
USD ($)
|
Dec. 31, 2013
Demand Deposits [Member]
USD ($)
|
Dec. 31, 2014
Money Market Funds [Member]
USD ($)
|
Dec. 31, 2013
Money Market Funds [Member]
USD ($)
|
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Cash and Cash Equivalents [Line Items] | |||||||||||||||||||||||||||||||||||
Cash equivalents | $ 10,800,000 | $ 18,900,000 | $ 67,600,000 | $ 82,800,000 | |||||||||||||||||||||||||||||||
Short-term Investments [Abstract] | |||||||||||||||||||||||||||||||||||
Short-term investments | 0 | 19,990,000 | |||||||||||||||||||||||||||||||||
Derivative [Line Items] | |||||||||||||||||||||||||||||||||||
Notional amount of derivative liability | 15,000,000 | ||||||||||||||||||||||||||||||||||
Number of foreign exchange option contracts | 2 | ||||||||||||||||||||||||||||||||||
Derivative, amount of hedged item | 1,500,000 | 15,000,000 | |||||||||||||||||||||||||||||||||
Derivative, premiums | 1,500,000 | ||||||||||||||||||||||||||||||||||
Derivative fair value | 0 | 400,000 | |||||||||||||||||||||||||||||||||
Derivative, loss | 400,000 | 100,000 | 700,000 | ||||||||||||||||||||||||||||||||
Receivables [Abstract] | |||||||||||||||||||||||||||||||||||
Trade receivables, net | 2,993,000 | 3,731,000 | |||||||||||||||||||||||||||||||||
Other receivables | 316,000 | 50,000 | |||||||||||||||||||||||||||||||||
Total | 3,309,000 | 3,781,000 | |||||||||||||||||||||||||||||||||
Property, Plant and Equipment [Line Items] | |||||||||||||||||||||||||||||||||||
Property and equipment, gross | 38,628,000 | 38,216,000 | 28,638,000 | 28,365,000 | 9,343,000 | 9,316,000 | 337,000 | 225,000 | 310,000 | 310,000 | |||||||||||||||||||||||||
Less: Accumulated depreciation and amortization | (33,508,000) | (31,760,000) | |||||||||||||||||||||||||||||||||
Property and equipment, net | 5,120,000 | 6,456,000 | |||||||||||||||||||||||||||||||||
Depreciation and amortization expense | 1,900,000 | 2,900,000 | 4,100,000 | ||||||||||||||||||||||||||||||||
Accrued Liabilities [Abstract] | |||||||||||||||||||||||||||||||||||
Incentive compensation | 4,295,000 | 4,386,000 | |||||||||||||||||||||||||||||||||
Accrued payroll and other benefits | 3,061,000 | 3,009,000 | |||||||||||||||||||||||||||||||||
Accrued clinical trial costs | 1,424,000 | 878,000 | |||||||||||||||||||||||||||||||||
Other | 1,112,000 | 1,661,000 | |||||||||||||||||||||||||||||||||
Total | 9,892,000 | 9,934,000 | |||||||||||||||||||||||||||||||||
Class of Warrant or Right [Line Items] | |||||||||||||||||||||||||||||||||||
Warrants outstanding (in shares) | 1,260,000 | 12,109,418 | 12,562,682 | 14,834,577 | 8,097,165 | 347,826 | |||||||||||||||||||||||||||||
Exercise price of warrants (in dollars per share) | $ 10.50 | $ 1.76 | $ 7.90 | $ 19.50 | |||||||||||||||||||||||||||||||
Fair value of warrant liability | 1,100,000 | 26,700,000 | 68,700,000 | 5,200,000 | 10,300,000 | 39,500,000 | 100,000 | ||||||||||||||||||||||||||||
Gain (loss) on revaluation of warrant liability | $ 1,100,000 | $ 5,100,000 | $ 2,500,000 | ||||||||||||||||||||||||||||||||
Warrant term | 5 years | 5 years | 2 years | 5 years |