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Subsequent Events (Details)
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12 Months Ended | 0 Months Ended | 0 Months Ended | 0 Months Ended | 0 Months Ended | 0 Months Ended | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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Dec. 31, 2014
USD ($)
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Dec. 31, 2014
Servier Loan [Member]
USD ($)
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Dec. 31, 2013
Servier Loan [Member]
USD ($)
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Jan. 09, 2015
Subsequent Event [Member]
Servier Loan [Member]
EUR (€)
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Jan. 09, 2015
Subsequent Event [Member]
Servier Loan [Member]
Tranche
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Jan. 09, 2015
Subsequent Event [Member]
Servier Loan [Member]
EURIBOR [Member]
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Jan. 09, 2015
Subsequent Event [Member]
Servier Loan [Member]
Tranche One [Member]
|
Jan. 09, 2015
Subsequent Event [Member]
Servier Loan [Member]
Tranche One [Member]
EUR (€)
|
Jan. 09, 2015
Subsequent Event [Member]
Servier Loan [Member]
Tranche Two [Member]
|
Jan. 09, 2015
Subsequent Event [Member]
Servier Loan [Member]
Tranche Two [Member]
EUR (€)
|
Jan. 09, 2015
Subsequent Event [Member]
Servier Loan [Member]
Tranche Three [Member]
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Jan. 09, 2015
Subsequent Event [Member]
Servier Loan [Member]
Tranche Three [Member]
EUR (€)
|
Feb. 27, 2015
Subsequent Event [Member]
Hercules Loan [Member]
USD ($)
|
Feb. 27, 2015
Subsequent Event [Member]
Hercules Loan [Member]
USD ($)
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| Subsequent Event [Line Items] | ||||||||||||||
| Date of agreement | Dec. 30, 2010 | |||||||||||||
| Date of agreement, after amendment | Aug. 12, 2013 | |||||||||||||
| Number of tranches | 3 | |||||||||||||
| Maturity date | Jan. 15, 2016 | Jan. 15, 2017 | Jan. 15, 2018 | Sep. 01, 2018 | ||||||||||
| Principal payment amount | € 3,000,000 | € 5,000,000 | € 7,000,000 | |||||||||||
| Variable rate basis | Euro Inter-Bank Offered Rate ("EURIBOR") | EURIBOR+2% | The interest rate will be calculated at a rate equal to the greater of either (i) 9.40% plus the prime rate as reported from time to time in The Wall Street Journal minus 7.25%, and (ii) 9.40%. | |||||||||||
| Basis spread on variable rate (in hundredths) | 2.00% | |||||||||||||
| Period of interest resetting | 6 months | |||||||||||||
| Eligible milestone payments receivable | 433,000,000 | |||||||||||||
| Eligible milestone payments receivable under specific rights not met | 770,000,000 | |||||||||||||
| Eligible milestone payments receivable, after amendment | 415,000,000 | |||||||||||||
| Eligible milestone payments receivable under specific rights not met, after amendment | 752,000,000 | |||||||||||||
| Borrowings | 35,537,000 | 16,200,000 | 16,500,000 | 20,000,000 | ||||||||||
| Outstanding principle balance and interest | 5,500,000 | |||||||||||||
| Percentage bearing variable rate (in hundredths) | 9.40% | |||||||||||||
| Reduction of percentage of interest under loan agreement (in hundredths) | 7.25% | |||||||||||||
| Period of interest | 1 month | |||||||||||||
| Amortization date | Jul. 01, 2016 | |||||||||||||
| Date of extension of amortization | Oct. 01, 2016 | |||||||||||||
| Period of principal and interest amortization | 30 months | |||||||||||||
| Loans payable | $ 1,150,000 | |||||||||||||
| Prepayment fee within twelve months of maturity (in hundredths) | 3.00% | |||||||||||||
| Prepayment fee after twelve months but before twenty four months of maturity (in hundredths) | 2.00% | |||||||||||||
| Prepayment fee after twenty four months of maturity (in hundredths) | 1.00% | |||||||||||||
| Additional interest rate in case of default (in hundredths) | 5.00% | |||||||||||||
| Warrants exercisable (in shares) | 181,268 | |||||||||||||
| Exercise price of warrants (in dollars per share) | $ 3.31 | |||||||||||||
| Exercisable period of warrants | 5 years | |||||||||||||