Quarterly report pursuant to Section 13 or 15(d)

Long-Term Debt - Servier Loan Agreement - Additional Information (Details)

v3.4.0.3
Long-Term Debt - Servier Loan Agreement - Additional Information (Details)
1 Months Ended 3 Months Ended 6 Months Ended 66 Months Ended
Jan. 09, 2015
USD ($)
Tranche
Jan. 31, 2016
EUR (€)
Jan. 31, 2011
USD ($)
Mar. 31, 2016
USD ($)
€ / $
Mar. 31, 2015
USD ($)
Jul. 31, 2016
Jul. 31, 2011
Jul. 15, 2016
Mar. 31, 2016
EUR (€)
€ / $
Dec. 31, 2015
USD ($)
€ / $
Jan. 09, 2015
EUR (€)
Tranche
Debt Instrument [Line Items]                      
Accrued interest paid       $ 646,000 $ 333,000            
Carrying value of the loan       46,251,000           $ 48,667,000  
Unrealized foreign exchange gain (loss)       $ (559,000) 1,949,000            
Servier Loan [Member]                      
Debt Instrument [Line Items]                      
Date of agreement       Dec. 30, 2010              
Maximum borrowing capacity under loan agreement | €                 € 15,000,000    
Proceeds from loan     $ 19,500,000                
Interest rate during period             3.22%        
Date of loan amendment       Jan. 09, 2015              
Date of agreement, after amendment       Aug. 12, 2013              
Number of tranches | Tranche 3                   3
Principal payment amount | €   € 3,000,000                  
Accrued interest paid | €   € 200,000                  
Unamortized discount on debt $ 1,900,000   $ 8,900,000                
Amortization of debt discount       $ 200,000 200,000            
Carrying value of the loan       12,700,000           15,300,000  
Unrealized foreign exchange gains related to re-measurement of loan discount       $ 38,000 200,000            
Agreement termination date       Sep. 28, 2015              
Agreement termination notice period       180 days              
Outstanding principal balance       $ 13,600,000           $ 16,400,000  
Euro to US Dollar exchange rates | € / $       1.136         1.136 1.091  
Unrealized foreign exchange gain (loss)       $ (500,000) $ 1,900,000            
Servier Loan [Member] | Tranche One [Member]                      
Debt Instrument [Line Items]                      
Maturity date Jan. 15, 2016                    
Principal payment amount | €                     € 3,000,000
Servier Loan [Member] | Tranche Two [Member]                      
Debt Instrument [Line Items]                      
Maturity date Jan. 15, 2017                    
Principal payment amount | €                     5,000,000
Servier Loan [Member] | Tranche Three [Member]                      
Debt Instrument [Line Items]                      
Maturity date Jan. 15, 2018                    
Principal payment amount | €                     € 7,000,000
Servier Loan [Member] | Mid-July 2015 Through Mid-January 2016 [Member]                      
Debt Instrument [Line Items]                      
Interest rate during period       2.05%              
Period of interest resetting       6 months              
Servier Loan [Member] | Forecast [Member]                      
Debt Instrument [Line Items]                      
Interest rates reset semi-annually, minimum               1.95%      
Interest rates reset semi-annually, maximum               3.83%      
Servier Loan [Member] | Forecast [Member] | Mid-January 2016 Through Mid-July 2016 [Member]                      
Debt Instrument [Line Items]                      
Interest rate during period           1.95%          
Period of interest resetting           6 months