Quarterly report pursuant to Section 13 or 15(d)

Long-Term Debt - Interest Expense and Amortization of Debt Issuance Costs (Details)

v3.4.0.3
Long-Term Debt - Interest Expense and Amortization of Debt Issuance Costs (Details) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2016
Mar. 31, 2015
Interest expense and amortization of debt issuance costs [Abstract]    
Interest expense $ 1,002 $ 1,115
Hercules Loan [Member]    
Interest expense and amortization of debt issuance costs [Abstract]    
Interest expense 672 234
Servier Loan [Member]    
Interest expense and amortization of debt issuance costs [Abstract]    
Interest expense 226 255
GECC Term Loan [Member]    
Interest expense and amortization of debt issuance costs [Abstract]    
Interest expense   548
Novartis Note [Member]    
Interest expense and amortization of debt issuance costs [Abstract]    
Interest expense 97 $ 78
Other [Member]    
Interest expense and amortization of debt issuance costs [Abstract]    
Interest expense $ 7