Annual report pursuant to Section 13 and 15(d)

Compensation and Other Benefit Plans (Details)

v2.4.0.8
Compensation and Other Benefit Plans (Details) (USD $)
12 Months Ended 3 Months Ended 12 Months Ended 12 Months Ended 3 Months Ended 12 Months Ended
Dec. 31, 2013
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2013
Research and Development [Member]
Dec. 31, 2012
Research and Development [Member]
Dec. 31, 2011
Research and Development [Member]
Dec. 31, 2013
Selling, General and Administrative [Member]
Dec. 31, 2012
Selling, General and Administrative [Member]
Dec. 31, 2011
Selling, General and Administrative [Member]
Dec. 31, 2013
Maximum [Member]
Dec. 31, 2013
Stock Options [Member]
Dec. 31, 2012
Stock Options [Member]
Dec. 31, 2011
Stock Options [Member]
Dec. 31, 2013
Stock Options [Member]
Directors [Member]
Minimum [Member]
Dec. 31, 2013
Stock Options [Member]
Directors [Member]
Maximum [Member]
Sep. 30, 2011
Stock Options [Member]
Chief Executive Officer [Member]
Dec. 31, 2013
Restricted Stock Units (RSUs) [Member]
Dec. 31, 2012
Restricted Stock Units (RSUs) [Member]
Dec. 31, 2011
Restricted Stock Units (RSUs) [Member]
Dec. 31, 2013
Employee Stock Purchase Plan [Member]
Dec. 31, 2012
Employee Stock Purchase Plan [Member]
Dec. 31, 2011
Employee Stock Purchase Plan [Member]
Dec. 31, 2013
Employee Stock Purchase Plan [Member]
Maximum [Member]
Dec. 31, 2013
Long Term Incentive Plan [Member]
Dec. 31, 2011
Long Term Incentive Plan [Member]
Stock Options [Member]
Dec. 31, 2013
Long Term Incentive Plan [Member]
Stock Options [Member]
Dec. 31, 2012
Long Term Incentive Plan [Member]
Stock Options [Member]
Dec. 31, 2013
Long Term Incentive Plan [Member]
Stock Options [Member]
Directors [Member]
Dec. 31, 2012
Long Term Incentive Plan [Member]
Stock Options [Member]
Directors [Member]
Dec. 31, 2013
Long Term Incentive Plan [Member]
Stock Options [Member]
Non-Executive Employees [Member]
Dec. 31, 2012
Long Term Incentive Plan [Member]
Stock Options [Member]
Non-Executive Employees [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                                                              
Vesting period                     4 years     1 year 3 years   3 years 3 years 3 years           2 years     1 year 1 year 4 years 4 years
Expiration period                     ten years from the date of the grant or three months from the date of termination of employment (longer in case of death or certain retirements).                         ten years from the date of the grant or three to six months from the date of termination of employment (longer in case of death or certain retirements).              
Purchase price to acquire shares (in hundredths)                                       95.00%                      
Shares authorized for issuance (in shares)                                       233,333       15,754,331              
Employee compensation available for share purchases, maximum (in hundredths)                                             15.00%                
Shares purchased (in shares)                                       15,262 17,054 30,044                  
Net payroll deductions to acquire shares                                       $ 60,000 $ 46,000 $ 54,000                  
Stock-based compensation charge                               700,000                              
Deferred savings plan [Abstract]                                                              
Maximum annual contribution per employee (in hundredths) 50.00%                                                            
Maximum annual contribution per employee 17,500                                                            
Maximum annual contribution per employee over 50 years old 23,000                                                            
Age requirement for participant to be eligible for a catch-up contribution, minimum 50 years                                                            
Employer matching contribution percentage, maximum (in hundredths)                   50.00%                                          
Deferred savings plan expense 900,000 800,000 1,100,000                                                        
Deferred savings plan expense paid in common shares (in hundredths) 100.00% 100.00% 100.00%                                                        
Number of shares of common stock to be issued upon exercise of options outstanding (in shares) 9,184,913                                                            
Stock option activity [Roll Forward]                                                              
Outstanding at beginning of year (in shares)                     6,788,383 5,053,435 2,331,450                                    
Granted (in shares)                     1,168,203 2,351,445 2,920,166                       1,097,926 1,168,203 2,351,445        
Exercised (in shares)                     (589,355) (90,252) 0                                    
Forfeited, expired or cancelled (in shares)                     (151,190) (526,245) (198,181)                                    
Outstanding at end of year (in shares)                     7,216,041 6,788,383 5,053,435                                    
Exercisable at end of year (in shares)                     4,814,926 4,276,834 3,366,807                                    
Stock options activity, weighted average exercise price [Roll Forward]                                                              
Outstanding at beginning of year (in dollars per share)                     $ 8.99 [1] $ 12.55 [1] $ 25.36 [1]                                    
Granted (in dollars per share)                     $ 3.13 [1] $ 2.59 [1] $ 2.81 [1]                                    
Exercised (in dollars per share)                     $ 2.26 [1] $ 1.68 [1] $ 0 [1]                                    
Forfeited, expired or cancelled (in dollars per share)                     $ 17.46 [1] $ 15.84 [1] $ 35.56 [1]                                    
Outstanding at end of year (in dollars per share)                     $ 8.42 [1] $ 8.99 [1] $ 12.55 [1]                                    
Exercisable at end of year (in dollars per share)                     $ 11.14 [1] $ 12.42 [1] $ 16.33 [1]                                    
Stock options vested and expected to vest [Abstract]                                                              
Options vested and expected to vest, number of shares (in shares)                     6,972,744                                        
Options vested and expected to vest, weighted-average exercise price (in dollars per share)                     $ 8.61                                        
Additional disclosures [Abstract]                                                              
Options outstanding, weighted average remaining contractual term                     6 years 6 months                                        
Options outstanding, aggregate intrinsic value                     18,200,000                                        
Options exercisable, weighted average remaining contractual term                     5 years 7 months 6 days                                        
Options exercisable, aggregate intrinsic value                     9,200,000                                        
Minimum age required for employees to qualify for immediate vesting of RSUs                                 55 years                            
Threshold years required for retirement age                                 70 years                            
Unvested RSU activity [Roll Forward]                                                              
Unvested balance, beginning of period (in shares)                                 1,459,853                            
Granted (in shares)                                 958,385 1,292,923 1,177,082                        
Vested (in shares)                                 (637,034)                            
Forfeited (in shares)                                 (43,167)                            
Unvested balance, end of period (in shares)                                 1,738,037 1,459,853                          
Unvested RSU activity, weighted average grant date fair value [Roll Forward]                                                              
Unvested balance, beginning of period (in dollars per share)                                 $ 2.75                            
Granted (in dollars per share)                                 $ 2.96                            
Vested (in dollars per share)                                 $ 2.57                            
Forfeited (in dollars per share)                                 $ 2.08                            
Unvested balance, end of period (in dollars per share)                                 $ 2.73 $ 2.75                          
Total grant-date fair value of RSUs, vested                                 958,385 1,600,000                          
Stock-based awards weighted average assumptions [Abstract]                                                              
Dividend yield (in hundredths) 0.00% 0.00% 0.00%                                                        
Expected volatility (in hundredths) 92.00% 92.00% 88.00%                                                        
Risk free interest rate (in hundredths) 0.89% 0.82% 1.48%                                                        
Expected term 5 years 7 months 6 days 5 years 7 months 6 days 5 years 4 months 24 days                                                        
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]                                                              
Total stock-based compensation expense 5,099,000 4,284,000 7,759,000 2,358,000 2,391,000 3,672,000 2,741,000 1,893,000 4,087,000                                            
Capitalized stock-based compensation cost 0 0                                                          
Tax benefits recognized related to stock-based compensation expense $ 0 $ 0                                                          
[1] Weighted-average exercise price.