Annual report pursuant to Section 13 and 15(d)

Commitments and Contingencies (Details)

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Commitments and Contingencies (Details) (USD $)
 12 Months Ended
Dec. 31, 2013
Dec. 31, 2012
Dec. 31, 2011
Commitments and Contingencies [Abstract]      
Royalties paid, minimum (in hundredths) 1.00%    
Royalties paid, maximum (in hundredths) 5.00%    
Sublicense fees paid, maximum (in hundredths) 40.00%    
Estimate of milestone payments $ 76,600,000    
Estimated future minimum lease commitments [Abstract]      
2014 3,661,000 [1]    
2015 3,640,000 [1]    
2016 3,749,000 [1]    
2017 3,862,000 [1]    
2018 3,978,000 [1]    
Thereafter 15,723,000 [1]    
Minimum lease payments 34,613,000 [1]    
Total rental expense 3,500,000 4,500,000 5,100,000
Restructuring charges 328,000 5,074,000 0
Sublease income 100,000    
Future sublease income $ 100,000    
[1] Operating leases are net of future sublease income of $0.1 million.