Quarterly report pursuant to Section 13 or 15(d)

Long-Term Debt - Interest Expense and Amortization of Debt Issuance Costs (Details)

v3.10.0.1
Long-Term Debt - Interest Expense and Amortization of Debt Issuance Costs (Details) - USD ($)
$ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Jun. 30, 2018
Jun. 30, 2017
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense $ 178 $ 297 $ 348 $ 906
Novartis Note [Member]        
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense 144 119 283 236
Servier Loan [Member]        
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense   $ 178   355
Hercules Loan [Member]        
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense       311
Other [Member]        
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense 22   53 $ 4
SVB Loan [Member]        
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense $ 12   $ 12