Annual report pursuant to Section 13 and 15(d)

Fair Value Measurements - Outstanding Long Term Debt Carrying Amount and Estimated Fair Value (Details)

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Fair Value Measurements - Outstanding Long Term Debt Carrying Amount and Estimated Fair Value (Details) - USD ($)
$ in Thousands
Dec. 31, 2018
Dec. 31, 2017
Carrying Amount [Member]    
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]    
Long-term debt $ 22,479 $ 14,572
Carrying Amount [Member] | Novartis Note [Member]    
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]    
Long-term debt 15,193 14,572
Carrying Amount [Member] | SVB Loan [Member]    
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]    
Long-term debt 7,286  
Fair Value [Member]    
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]    
Long-term debt 22,106 14,178
Fair Value [Member] | Novartis Note [Member]    
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]    
Long-term debt 14,825 $ 14,178
Fair Value [Member] | SVB Loan [Member]    
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]    
Long-term debt $ 7,281