Annual report pursuant to Section 13 and 15(d)

Long-Term Debt and Other Financings - Interest Expense and Amortization of Debt Issuance Costs (Details)

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Long-Term Debt and Other Financings - Interest Expense and Amortization of Debt Issuance Costs (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Interest expense and amortization of debt issuance costs [Abstract]    
Interest expense $ 922 $ 1,238
Hercules Loan [Member]    
Interest expense and amortization of debt issuance costs [Abstract]    
Interest expense   311
SVB Loan [Member]    
Interest expense and amortization of debt issuance costs [Abstract]    
Interest expense 258  
Servier Loan [Member]    
Interest expense and amortization of debt issuance costs [Abstract]    
Interest expense   431
Novartis Note [Member]    
Interest expense and amortization of debt issuance costs [Abstract]    
Interest expense 627 490
Other [Member]    
Interest expense and amortization of debt issuance costs [Abstract]    
Interest expense $ 37 $ 6