Quarterly report pursuant to Section 13 or 15(d)

Fair Value Measurements - Outstanding Debt Carrying Amount and Estimated Fair Value (Details)

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Fair Value Measurements - Outstanding Debt Carrying Amount and Estimated Fair Value (Details) - USD ($)
$ in Thousands
Jun. 30, 2016
Dec. 31, 2015
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]    
Interest-bearing obligations, Carrying amount $ 46,524 $ 48,667
Interest bearing obligations, Estimated Fair value 47,422 49,810
Hercules Term Loan [Member]    
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]    
Interest-bearing obligations, Carrying amount 20,052 19,653
Interest bearing obligations, Estimated Fair value 21,225 21,231
Novartis Note [Member]    
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]    
Interest-bearing obligations, Carrying amount 13,879 13,683
Interest bearing obligations, Estimated Fair value 13,641 13,394
Servier Loan [Member]    
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]    
Interest-bearing obligations, Carrying amount 12,593 15,331
Interest bearing obligations, Estimated Fair value $ 12,556 $ 15,185