Quarterly report pursuant to Section 13 or 15(d)

Long-Term Debt - Servier Loan Agreement - Additional Information (Details)

v3.5.0.2
Long-Term Debt - Servier Loan Agreement - Additional Information (Details)
 1 Months Ended 3 Months Ended 6 Months Ended
Jan. 09, 2015
USD ($)
Tranche
Jan. 31, 2016
EUR (€)
Jan. 31, 2011
USD ($)
Jun. 30, 2016
USD ($)
€ / $
Jun. 30, 2015
USD ($)
Jul. 31, 2016
Jun. 30, 2016
USD ($)
€ / $
Jun. 30, 2015
USD ($)
Jul. 31, 2011
Jul. 15, 2016
Jun. 30, 2016
EUR (€)
€ / $
Dec. 31, 2015
USD ($)
€ / $
Jan. 09, 2015
EUR (€)
Tranche
Debt Instrument [Line Items]                          
Accrued interest paid             $ 1,127,000 $ 792,000          
Carrying value of the loan       $ 46,524,000     $ 46,524,000         $ 48,667,000  
Servier Loan [Member]                          
Debt Instrument [Line Items]                          
Date of agreement             Dec. 30, 2010            
Maximum borrowing capacity under loan agreement | €                     € 15,000,000    
Proceeds from loan     $ 19,500,000                    
Interest rate during period                 3.22%        
Date of loan amendment             Jan. 09, 2015            
Date of agreement, after amendment             Aug. 12, 2013            
Number of tranches | Tranche 3                       3
Principal payment amount | €   € 3,000,000                      
Accrued interest paid | €   € 200,000                      
Unamortized discount on debt $ 1,900,000   $ 8,900,000                    
Amortization of debt discount       200,000 $ 200,000   $ 300,000 300,000          
Carrying value of the loan       12,600,000     12,600,000         15,300,000  
Unrealized foreign exchange gains (loss) related to re-measurement of loan discount       (17,000) 35,000   $ 20,000 (200,000)          
Agreement termination date             Sep. 28, 2015            
Agreement termination notice period             180 days            
Outstanding principal balance       $ 13,300,000     $ 13,300,000         $ 16,400,000  
Euro to US Dollar exchange rates | € / $       1.110     1.110       1.110 1.091  
Unrealized foreign exchange gains (loss) related to re-measurement of loan       $ 300,000 $ (400,000)   $ (200,000) $ 1,600,000          
Servier Loan [Member] | Tranche One [Member]                          
Debt Instrument [Line Items]                          
Maturity date Jan. 15, 2016                        
Principal payment amount | €                         € 3,000,000
Servier Loan [Member] | Tranche Two [Member]                          
Debt Instrument [Line Items]                          
Maturity date Jan. 15, 2017                        
Principal payment amount | €                         5,000,000
Servier Loan [Member] | Tranche Three [Member]                          
Debt Instrument [Line Items]                          
Maturity date Jan. 15, 2018                        
Principal payment amount | €                         € 7,000,000
Servier Loan [Member] | Mid-July 2015 Through Mid-January 2016 [Member]                          
Debt Instrument [Line Items]                          
Interest rate during period             2.05%            
Period of interest resetting             6 months            
Servier Loan [Member] | Subsequent Event [Member] | Minimum [Member]                          
Debt Instrument [Line Items]                          
Interest rates reset semi-annually                   1.95%      
Servier Loan [Member] | Subsequent Event [Member] | Maximum [Member]                          
Debt Instrument [Line Items]                          
Interest rates reset semi-annually                   3.83%      
Servier Loan [Member] | Subsequent Event [Member] | Mid-January 2016 Through Mid-July 2016 [Member]                          
Debt Instrument [Line Items]                          
Interest rate during period           1.95%              
Period of interest resetting           6 months