Quarterly report pursuant to Section 13 or 15(d)

Long-Term Debt - Interest Expense and Amortization of Debt Issuance Costs (Details)

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Long-Term Debt - Interest Expense and Amortization of Debt Issuance Costs (Details) - USD ($)
$ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2016
Jun. 30, 2015
Jun. 30, 2016
Jun. 30, 2015
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense $ 1,007 $ 1,007 $ 2,009 $ 2,123
Hercules Term Loan [Member]        
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense 679 652 1,351 886
Servier Loan [Member]        
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense 225 272 451 527
GECC Term Loan [Member]        
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense       548
Novartis Note [Member]        
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense 98 80 195 159
Other [Member]        
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense $ 5 $ 3 $ 12 $ 3