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Long-Term Debt and Other Financings (Details) (USD $)
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3 Months Ended | 6 Months Ended | 3 Months Ended | 6 Months Ended | 3 Months Ended | 6 Months Ended | 3 Months Ended | 6 Months Ended | 12 Months Ended | 3 Months Ended | 6 Months Ended | 17 Months Ended | ||||||||||||||
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Jun. 30, 2012
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Jun. 30, 2011
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Jun. 30, 2012
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Jun. 30, 2011
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Jun. 30, 2012
Novartis Note [Member]
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Jun. 30, 2011
Novartis Note [Member]
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Jun. 30, 2012
Novartis Note [Member]
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Jun. 30, 2011
Novartis Note [Member]
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Dec. 31, 2011
Novartis Note [Member]
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Jun. 30, 2012
Novartis Note [Member]
Maximum [Member]
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Jun. 30, 2012
Servier Loan [Member]
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Jun. 30, 2011
Servier Loan [Member]
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Dec. 31, 2012
Servier Loan [Member]
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Jun. 30, 2012
Servier Loan [Member]
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Jun. 30, 2011
Servier Loan [Member]
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Dec. 31, 2011
Servier Loan [Member]
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Jun. 30, 2012
General Electric Capital Corporation Term Loan [Member]
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Jun. 30, 2011
General Electric Capital Corporation Term Loan [Member]
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Jun. 30, 2012
General Electric Capital Corporation Term Loan [Member]
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Jun. 30, 2011
General Electric Capital Corporation Term Loan [Member]
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Dec. 31, 2011
General Electric Capital Corporation Term Loan [Member]
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Jun. 30, 2012
Other Financings [Member]
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Jun. 30, 2011
Other Financings [Member]
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Jun. 30, 2012
Other Financings [Member]
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Jun. 30, 2011
Other Financings [Member]
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Jun. 30, 2012
Other Financings [Member]
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| Novartis Note [Abstract] | ||||||||||||||||||||||||||
| Maturity date | Jun. 30, 2015 | Jun. 30, 2015 | ||||||||||||||||||||||||
| Maximum percentage for semi-annual borrowings (in hundredths) | 75.00% | 75.00% | ||||||||||||||||||||||||
| Aggregate principal amount | $ 50,000,000 | $ 10,000,000 | ||||||||||||||||||||||||
| Variable rate basis | six-month LIBOR | |||||||||||||||||||||||||
| Basis spread on variable rate (in hundredths) | 2.00% | 2.00% | ||||||||||||||||||||||||
| Interest rate at period end (in hundredths) | 2.74% | 2.74% | ||||||||||||||||||||||||
| Outstanding principal balance | 14,200,000 | 14,200,000 | 14,000,000 | 18,900,000 | 18,900,000 | 19,400,000 | 8,600,000 | 8,600,000 | 10,000,000 | |||||||||||||||||
| Servier Loan [Abstract] | ||||||||||||||||||||||||||
| Maximum borrowing capacity under loan agreement | 15,000,000 | 15,000,000 | ||||||||||||||||||||||||
| Proceeds from loan | 19,500,000 | |||||||||||||||||||||||||
| Interest rate during period (in hundredths) | 3.54% | 3.83% | ||||||||||||||||||||||||
| Initial interest rate during period (in hundredths) | 2.80% | 3.22% | ||||||||||||||||||||||||
| Servier loan maturity year | 2016 | |||||||||||||||||||||||||
| Recorded unrealized foreign exchange losses | 383,000 | (1,876,000) | 1,100,000 | 2,100,000 | 500,000 | 500,000 | ||||||||||||||||||||
| Unamortized discount on debt | 0 | 8,899,000 | 0 | 8,899,000 | 8,900,000 | 8,900,000 | ||||||||||||||||||||
| Amortization period for loan discount | 5 years | |||||||||||||||||||||||||
| Amortization of debt discount | 300,000 | 400,000 | 700,000 | 700,000 | 200,000 | |||||||||||||||||||||
| Carrying value of the loan | 12,800,000 | 12,800,000 | 12,500,000 | |||||||||||||||||||||||
| Unrealized foreign exchange loss related to re-measurement of loan discount | 400,000 | 200,000 | 400,000 | 200,000 | ||||||||||||||||||||||
| Unrealized foreign exchange gains related to re-measurement of loan discount | 200,000 | 200,000 | ||||||||||||||||||||||||
| Recognition of deferred revenue | 300,000 | 400,000 | 700,000 | 700,000 | ||||||||||||||||||||||
| General Electric Capital Corporation Term Loan [Abstract] | ||||||||||||||||||||||||||
| Number of principal subsidiaries | 2 | |||||||||||||||||||||||||
| Debt issuance costs | 1,300,000 | |||||||||||||||||||||||||
| Final payment fee (in hundredths) | 5.00% | |||||||||||||||||||||||||
| Fixed interest rate accrued (in hundredths) | 11.71% | |||||||||||||||||||||||||
| Number of monthly installments | 42 | |||||||||||||||||||||||||
| Debt default interest rate terms | bear interest from and after the occurrence and during the continuation of an event of default at a rate equal to the lesser of 5.0% above the stated rate of interest or the maximum rate allowed by law. | |||||||||||||||||||||||||
| Prepayment premium year one (in hundredths) | 3.00% | |||||||||||||||||||||||||
| Prepayment premium year two (in hundredths) | 2.00% | |||||||||||||||||||||||||
| Prepayment premium year thereafter (in hundredths) | 1.00% | |||||||||||||||||||||||||
| Aggregate number of unregistered shares of common stock (in shares) | 263,158 | |||||||||||||||||||||||||
| Warrants exercise price (in dollars per share) | $ 1.76 | $ 1.76 | $ 1.14 | |||||||||||||||||||||||
| Warrants exercisable and expiration date | Dec. 30, 2016 | |||||||||||||||||||||||||
| Interest expense | 1,025,000 | 634,000 | 2,068,000 | 1,166,000 | 99,000 | 85,000 | 199,000 | 169,000 | 509,000 | 538,000 | 1,025,000 | 980,000 | 406,000 | 0 | 823,000 | 0 | 11,000 | 11,000 | 21,000 | 17,000 | ||||||
| ATM Agreement [Abstract] | ||||||||||||||||||||||||||
| Common stock sold (in shares) | 2,285,375 | 7,572,327 | ||||||||||||||||||||||||
| Proceeds from issuance of common stock | 39,426,000 | 9,910,000 | 3,300,000 | 14,600,000 | ||||||||||||||||||||||
| Offering costs | 100,000 | 400,000 | ||||||||||||||||||||||||
| Underwritten offering and amendment to shareholder rights plan [Abstract] | ||||||||||||||||||||||||||
| Underwritten public offering shares of common stock (in shares) | 29,669,154 | |||||||||||||||||||||||||
| Public offering price (in dollars per share) | $ 1.32 | $ 1.32 | ||||||||||||||||||||||||
| Total gross proceeds from offering | 39,200,000 | |||||||||||||||||||||||||
| Underwriting discounts, commissions and estimated offering expenses | $ 3,000,000 | |||||||||||||||||||||||||
| Warrants outstanding (in shares) | 14,834,577 | 14,834,577 | ||||||||||||||||||||||||
| Percentage of beneficial ownership (in hundredths) | 20.00% | 20.00% | ||||||||||||||||||||||||
| Percentage of common stock ownership (in hundredths) | 40.00% | 40.00% | ||||||||||||||||||||||||
| Number of times the market value of common stock exercise price | 2 | 2 | ||||||||||||||||||||||||