Quarterly report pursuant to Section 13 or 15(d)

Stock-based Compensation (Details)

v2.4.0.6
Stock-based Compensation (Details) (USD $)
In Thousands, except Share data, unless otherwise specified
 3 Months Ended 6 Months Ended 12 Months Ended
Jun. 30, 2012
Jun. 30, 2011
Jun. 30, 2012
Jun. 30, 2011
Dec. 31, 2011
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]          
Total stock-based compensation expense $ 572 2,284 $ 1,246 4,056  
Research and Development [Member]
          
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]          
Total stock-based compensation expense 295 885 680 1,946  
Selling, General and Administrative Expenses [Member]
          
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]          
Total stock-based compensation expense 277 1,399 566 2,110  
Stock Options [Member]
          
Stock-based awards weighted average assumptions [Abstract]          
Dividend yield (in hundredths) 0.00% 0.00% 0.00% 0.00%  
Expected volatility (in hundredths) 92.00% 87.00% 92.00% 87.00%  
Risk free interest rate (in hundredths) 0.72% 1.76% 1.02% 1.87%  
Expected term 5 years 7 months 6 days 5 years 7 months 6 days 5 years 7 months 6 days 5 years 3 months 18 days  
Stock option activity [Roll Forward]          
Options outstanding beginning of period (in shares)     5,053,435    
Granted (in shares)     1,043,550    
Exercised (in shares)     (49,864)    
Forfeited, expired or cancelled (in shares)     (337,522)    
Options outstanding end of period (in shares) 5,709,599   5,709,599   5,053,435
Options exercisable at end period (in shares) 3,745,862   3,745,862    
Stock options activity, weighted average exercise price [Roll Forward]          
Options outstanding, beginning of period (in dollars per share)     $ 12.55    
Granted (in dollars per share)     $ 1.54    
Exercised (in dollars per share)     $ 1.69    
Forfeited, expired or cancelled (in dollars per share)     $ 20.18    
Options outstanding, end of period (in dollars per share) $ 10.18   $ 10.18   $ 12.55
Options exercisable weighted average exercise price (in dollars per share) $ 13.79   $ 13.79    
Additional Disclosures [Abstract]          
Options outstanding weighted average remaining contractual term beginning of period     7 years 2 months 12 days   6 years 10 months 20 days
Options outstanding weighted average remaining contractual term end of period     7 years 2 months 12 days   6 years 10 months 20 days
Options exercisable weighted average remaining contractual term     6 years 5 months 12 days    
Options outstanding, aggregate intrinsic value at beginning of period     0    
Options outstanding, aggregate intrinsic value at end of period 2,790   2,790   0
Options exercisable, aggregate intrinsic value $ 1,152   $ 1,152    
Restricted Stock Units (RSUs) [Member]
          
Unvested RSU activity [Roll Forward]          
Unvested balance beginning of period (in shares)     903,874    
Granted (in shares)     391,765    
Vested (in shares)     (9,231)    
Forfeited (in shares)     (181,030)    
Unvested balance end of period (in shares) 1,105,378   1,105,378    
Share-based , nonvested, weighted average grant date fair value [Roll Forward]          
Unvested balance beginning of period (in dollars per share)     $ 1.69    
Granted (in dollars per share)     $ 1.42    
Vested (in dollars per share)     $ 1.69    
Forfeited (in dollars per share)     $ 1.69    
Unvested balance end of period (in dollars per share) $ 1.59   $ 1.59