Annual report pursuant to Section 13 and 15(d)

CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS

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CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS (USD $)
In Thousands, except Per Share data, unless otherwise specified
 12 Months Ended
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Revenues:      
License and collaborative fees $ 5,727 $ 17,991 $ 2,182
Contract and other 26,852 40,037 27,174
Net product sales 1,044 0 0
Royalties 159 168 4,285
Total revenues 33,782 58,196 33,641
Operating expenses:      
Research and development 68,231 68,137 77,413
Selling, general and administrative 16,782 24,014 23,250
Restructuring 5,074 0 82
Cost of sales 143 0 0
Total operating expenses 90,230 92,151 100,745
Loss from operations (56,448) (33,955) (67,104)
Other income (expense):      
Interest expense (4,387) (2,462) (385)
Other expense (956) (177) (3,523)
Revaluation of contingent warrant liabilities (9,172) 3,866 2,283
Net loss before taxes (70,963) (32,728) (68,729)
Provision for income tax benefit (expense) 74 (15) (27)
Net loss (70,889) (32,743) (68,756)
Basic and diluted net loss per share of common stock (in dollars per share) $ (1.1) $ (1.04) $ (3.69)
Shares used in computing basic and diluted net loss per share of common stock (in shares) 64,629 31,590 18,613
Comprehensive loss:      
Net unrealized gains on available-for-sale securities 8 0 0
Comprehensive loss $ (70,881) $ (32,743) $ (68,756)