Annual report pursuant to Section 13 and 15(d)

Compensation and Other Benefit Plans (Details)

v2.4.0.6
Compensation and Other Benefit Plans (Details) (USD $)
12 Months Ended 3 Months Ended 12 Months Ended 3 Months Ended 12 Months Ended 12 Months Ended 3 Months Ended 12 Months Ended 3 Months Ended 12 Months Ended 3 Months Ended 12 Months Ended
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Dec. 31, 2012
Research and Development [Member]
Dec. 31, 2011
Research and Development [Member]
Dec. 31, 2010
Research and Development [Member]
Dec. 31, 2012
Selling, General and Administrative [Member]
Dec. 31, 2011
Selling, General and Administrative [Member]
Dec. 31, 2010
Selling, General and Administrative [Member]
Dec. 31, 2012
Maximum [Member]
Mar. 31, 2010
Stock Options [Member]
Dec. 31, 2012
Stock Options [Member]
Dec. 31, 2011
Stock Options [Member]
Dec. 31, 2010
Stock Options [Member]
Dec. 31, 2012
Stock Options [Member]
Directors [Member]
Minimum [Member]
Dec. 31, 2012
Stock Options [Member]
Directors [Member]
Maximum [Member]
Sep. 30, 2011
Stock Options [Member]
Chief Executive Officer [Member]
Dec. 31, 2012
Restricted Stock Units (RSUs) [Member]
Dec. 31, 2011
Restricted Stock Units (RSUs) [Member]
Dec. 31, 2012
Employee Stock Purchase Plan [Member]
Dec. 31, 2011
Employee Stock Purchase Plan [Member]
Dec. 31, 2010
Employee Stock Purchase Plan [Member]
Dec. 31, 2012
Employee Stock Purchase Plan [Member]
Maximum [Member]
Dec. 31, 2012
Long Term Incentive Plan [Member]
Dec. 31, 2011
Long Term Incentive Plan [Member]
Stock Options [Member]
Jun. 30, 2011
Long Term Incentive Plan [Member]
Stock Options [Member]
Mar. 31, 2011
Long Term Incentive Plan [Member]
Stock Options [Member]
Dec. 31, 2012
Long Term Incentive Plan [Member]
Stock Options [Member]
Mar. 31, 2011
Long Term Incentive Plan [Member]
Stock Options [Member]
Directors [Member]
Dec. 31, 2012
Long Term Incentive Plan [Member]
Stock Options [Member]
Directors [Member]
Mar. 31, 2011
Long Term Incentive Plan [Member]
Stock Options [Member]
Non-Executive Employees [Member]
Dec. 31, 2012
Long Term Incentive Plan [Member]
Stock Options [Member]
Non-Executive Employees [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                                                                
Vesting period                     4 years 4 years     1 year 3 years   3 years 3 years           2 years       1 year 1 year 2 years 4 years
Expiration period                       ten years from the date of the grant or three months from the date of termination of employment (longer in case of death or certain retirements).                       ten years from the date of the grant or three to six months from the date of termination of employment (longer in case of death or certain retirements).                
Purchase price to acquire shares (in hundredths)                                       95.00%                        
Shares authorized for issuance (in shares)                                       233,333       15,754,331                
Employee compensation available for share purchases, maximum (in hundredths)                                             15.00%                  
Shares purchased (in shares)                                       17,054 30,044 5,903                    
Net payroll deductions to acquire shares                                       $ 46,000 $ 54,000 $ 41,000                    
Additional shares authorized for issuance (in shares)                     596,666                             1,040,220            
Options issued under the Company's annual compensation review (in shares)                     856,006                                          
Deferred savings plan [Abstract]                                                                
Maximum annual contribution per employee (in hundredths) 50.00%                                                              
Maximum annual contribution per employee 17,000                                                              
Maximum annual contribution per employee over 50 years old 22,500                                                              
Age requirement for participant to be eligible for a catch-up contribution, minimum 50 years                                                              
Employer matching contribution percentage, maximum (in hundredths)                   50.00%                                            
Deferred savings plan expense 800,000 1,100,000 1,000,000                                                          
Deferred savings plan expense paid in common shares (in hundredths) 100.00% 100.00% 100.00%                                                          
Number of shares of common stock to be issued upon exercise of options outstanding (in shares) 8,649,331                                                              
Stock option activity [Roll Forward]                                                                
Outstanding at beginning of year (in shares)                     1,520,102 5,053,435 2,331,450 1,520,102                                    
Granted (in shares)                     865,806 2,351,445 2,920,166 978,264                     1,097,926   1,430,840 2,351,445        
Exercised (in shares)                       (90,252) 0 (19)                                    
Forfeited, expired or cancelled (in shares)                       (526,245) (198,181) (166,897)                                    
Outstanding at end of year (in shares)                       6,788,383 5,053,435 2,331,450                                    
Exercisable at end of year (in shares)                       4,276,834 3,366,807 1,259,272                                    
Stock options activity, weighted average exercise price [Roll Forward]                                                                
Outstanding at beginning of year (in dollars per share)                     $ 38.40 [1] $ 12.55 [1] $ 25.36 [1] $ 38.40 [1]                                    
Granted (in dollars per share)                       $ 2.59 [1] $ 2.81 [1] $ 7.07 [1]                                    
Exercised (in dollars per share)                       $ 1.68 [1] $ 0 [1] $ 8.40 [1]                                    
Forfeited, expired or cancelled (in dollars per share)                       $ 15.84 [1] $ 35.56 [1] $ 37.26 [1]                                    
Outstanding at end of year (in dollars per share)                       $ 8.99 [1] $ 12.55 [1] $ 25.36 [1]                                    
Exercisable at end of year (in dollars per share)                       $ 12.42 [1] $ 16.33 [1] $ 36.51 [1]                                    
Stock options vested and expected to vest [Abstract]                                                                
Options vested and expected to vest, number of shares (in shares)                       6,484,641                                        
Options vested and expected to vest, weighted-average exercise price (in dollars per share)                       $ 9.28                                        
Additional disclosures [Abstract]                                                                
Options outstanding, weighted average remaining contractual term                       7 years 4 months 24 days                                        
Options outstanding, aggregate intrinsic value                       1,500,000                                        
Options exercisable, weighted average remaining contractual term                       6 years 6 months                                        
Options exercisable, aggregate intrinsic value                       800,000                                        
Minimum age required for employees to qualify for immediate vesting of RSUs 55                                                              
Threshold years required for retirement age 70 years                                                              
Unvested RSU activity [Roll Forward]                                                                
Unvested balance, beginning of period (in shares)                                   903,874                            
Granted (in shares)                                   1,292,923 1,177,082                          
Vested (in shares)                                   (590,862)                            
Forfeited (in shares)                                   (212,055)                            
Unvested balance, end of period (in shares)                                   1,393,880 903,874                          
Unvested RSU activity, weighted average grant date fair value [Roll Forward]                                                                
Unvested balance, beginning of period (in dollars per share)                                   $ 1.69                            
Granted (in dollars per share)                                   $ 2.83                            
Vested (in dollars per share)                                   $ 2.27                            
Forfeited (in dollars per share)                                   $ 1.69                            
Unvested balance, end of period (in dollars per share)                                   $ 2.75 $ 1.69                          
Total grant-date fair value of RSUs, vested                                   1,300,000                            
Stock-based awards weighted average assumptions [Abstract]                                                                
Dividend yield (in hundredths) 0.00% 0.00% 0.00%                                                          
Expected volatility (in hundredths) 92.00% 88.00% 79.00%                                                          
Risk free interest rate (in hundredths) 0.82% 1.48% 1.67%                                                          
Expected term 5 years 7 months 6 days 5 years 4 months 24 days 5 years 3 months 18 days                                                          
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]                                                                
Total stock-based compensation expense 4,284,000 7,759,000 4,913,000 2,391,000 3,672,000 2,302,000 1,893,000 4,087,000 2,611,000               700,000                              
Capitalized stock-based compensation cost 0 0                                                            
Tax benefits recognized related to stock-based compensation expense $ 0 $ 0                                                            
[1] Weighted-average exercise price