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Compensation and Other Benefit Plans (Details) (USD $)
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12 Months Ended | 3 Months Ended | 12 Months Ended | 3 Months Ended | 12 Months Ended | 12 Months Ended | 3 Months Ended | 12 Months Ended | 3 Months Ended | 12 Months Ended | 3 Months Ended | 12 Months Ended | ||||||||||||||||||||||||||
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Dec. 31, 2012
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Dec. 31, 2011
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Dec. 31, 2010
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Dec. 31, 2012
Research and Development [Member]
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Dec. 31, 2011
Research and Development [Member]
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Dec. 31, 2010
Research and Development [Member]
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Dec. 31, 2012
Selling, General and Administrative [Member]
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Dec. 31, 2011
Selling, General and Administrative [Member]
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Dec. 31, 2010
Selling, General and Administrative [Member]
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Dec. 31, 2012
Maximum [Member]
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Mar. 31, 2010
Stock Options [Member]
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Dec. 31, 2012
Stock Options [Member]
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Dec. 31, 2011
Stock Options [Member]
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Dec. 31, 2010
Stock Options [Member]
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Dec. 31, 2012
Stock Options [Member]
Directors [Member]
Minimum [Member]
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Dec. 31, 2012
Stock Options [Member]
Directors [Member]
Maximum [Member]
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Sep. 30, 2011
Stock Options [Member]
Chief Executive Officer [Member]
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Dec. 31, 2012
Restricted Stock Units (RSUs) [Member]
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Dec. 31, 2011
Restricted Stock Units (RSUs) [Member]
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Dec. 31, 2012
Employee Stock Purchase Plan [Member]
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Dec. 31, 2011
Employee Stock Purchase Plan [Member]
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Dec. 31, 2010
Employee Stock Purchase Plan [Member]
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Dec. 31, 2012
Employee Stock Purchase Plan [Member]
Maximum [Member]
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Dec. 31, 2012
Long Term Incentive Plan [Member]
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Dec. 31, 2011
Long Term Incentive Plan [Member]
Stock Options [Member]
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Jun. 30, 2011
Long Term Incentive Plan [Member]
Stock Options [Member]
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Mar. 31, 2011
Long Term Incentive Plan [Member]
Stock Options [Member]
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Dec. 31, 2012
Long Term Incentive Plan [Member]
Stock Options [Member]
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Mar. 31, 2011
Long Term Incentive Plan [Member]
Stock Options [Member]
Directors [Member]
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Dec. 31, 2012
Long Term Incentive Plan [Member]
Stock Options [Member]
Directors [Member]
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Mar. 31, 2011
Long Term Incentive Plan [Member]
Stock Options [Member]
Non-Executive Employees [Member]
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Dec. 31, 2012
Long Term Incentive Plan [Member]
Stock Options [Member]
Non-Executive Employees [Member]
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| Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||||||||||||||||||||||||||||||||||||||
| Vesting period | 4 years | 4 years | 1 year | 3 years | 3 years | 3 years | 2 years | 1 year | 1 year | 2 years | 4 years | |||||||||||||||||||||||||||
| Expiration period | ten years from the date of the grant or three months from the date of termination of employment (longer in case of death or certain retirements). | ten years from the date of the grant or three to six months from the date of termination of employment (longer in case of death or certain retirements). | ||||||||||||||||||||||||||||||||||||
| Purchase price to acquire shares (in hundredths) | 95.00% | |||||||||||||||||||||||||||||||||||||
| Shares authorized for issuance (in shares) | 233,333 | 15,754,331 | ||||||||||||||||||||||||||||||||||||
| Employee compensation available for share purchases, maximum (in hundredths) | 15.00% | |||||||||||||||||||||||||||||||||||||
| Shares purchased (in shares) | 17,054 | 30,044 | 5,903 | |||||||||||||||||||||||||||||||||||
| Net payroll deductions to acquire shares | $ 46,000 | $ 54,000 | $ 41,000 | |||||||||||||||||||||||||||||||||||
| Additional shares authorized for issuance (in shares) | 596,666 | 1,040,220 | ||||||||||||||||||||||||||||||||||||
| Options issued under the Company's annual compensation review (in shares) | 856,006 | |||||||||||||||||||||||||||||||||||||
| Deferred savings plan [Abstract] | ||||||||||||||||||||||||||||||||||||||
| Maximum annual contribution per employee (in hundredths) | 50.00% | |||||||||||||||||||||||||||||||||||||
| Maximum annual contribution per employee | 17,000 | |||||||||||||||||||||||||||||||||||||
| Maximum annual contribution per employee over 50 years old | 22,500 | |||||||||||||||||||||||||||||||||||||
| Age requirement for participant to be eligible for a catch-up contribution, minimum | 50 years | |||||||||||||||||||||||||||||||||||||
| Employer matching contribution percentage, maximum (in hundredths) | 50.00% | |||||||||||||||||||||||||||||||||||||
| Deferred savings plan expense | 800,000 | 1,100,000 | 1,000,000 | |||||||||||||||||||||||||||||||||||
| Deferred savings plan expense paid in common shares (in hundredths) | 100.00% | 100.00% | 100.00% | |||||||||||||||||||||||||||||||||||
| Number of shares of common stock to be issued upon exercise of options outstanding (in shares) | 8,649,331 | |||||||||||||||||||||||||||||||||||||
| Stock option activity [Roll Forward] | ||||||||||||||||||||||||||||||||||||||
| Outstanding at beginning of year (in shares) | 1,520,102 | 5,053,435 | 2,331,450 | 1,520,102 | ||||||||||||||||||||||||||||||||||
| Granted (in shares) | 865,806 | 2,351,445 | 2,920,166 | 978,264 | 1,097,926 | 1,430,840 | 2,351,445 | |||||||||||||||||||||||||||||||
| Exercised (in shares) | (90,252) | 0 | (19) | |||||||||||||||||||||||||||||||||||
| Forfeited, expired or cancelled (in shares) | (526,245) | (198,181) | (166,897) | |||||||||||||||||||||||||||||||||||
| Outstanding at end of year (in shares) | 6,788,383 | 5,053,435 | 2,331,450 | |||||||||||||||||||||||||||||||||||
| Exercisable at end of year (in shares) | 4,276,834 | 3,366,807 | 1,259,272 | |||||||||||||||||||||||||||||||||||
| Stock options activity, weighted average exercise price [Roll Forward] | ||||||||||||||||||||||||||||||||||||||
| Outstanding at beginning of year (in dollars per share) | $ 38.40 | [1] | $ 12.55 | [1] | $ 25.36 | [1] | $ 38.40 | [1] | ||||||||||||||||||||||||||||||
| Granted (in dollars per share) | $ 2.59 | [1] | $ 2.81 | [1] | $ 7.07 | [1] | ||||||||||||||||||||||||||||||||
| Exercised (in dollars per share) | $ 1.68 | [1] | $ 0 | [1] | $ 8.40 | [1] | ||||||||||||||||||||||||||||||||
| Forfeited, expired or cancelled (in dollars per share) | $ 15.84 | [1] | $ 35.56 | [1] | $ 37.26 | [1] | ||||||||||||||||||||||||||||||||
| Outstanding at end of year (in dollars per share) | $ 8.99 | [1] | $ 12.55 | [1] | $ 25.36 | [1] | ||||||||||||||||||||||||||||||||
| Exercisable at end of year (in dollars per share) | $ 12.42 | [1] | $ 16.33 | [1] | $ 36.51 | [1] | ||||||||||||||||||||||||||||||||
| Stock options vested and expected to vest [Abstract] | ||||||||||||||||||||||||||||||||||||||
| Options vested and expected to vest, number of shares (in shares) | 6,484,641 | |||||||||||||||||||||||||||||||||||||
| Options vested and expected to vest, weighted-average exercise price (in dollars per share) | $ 9.28 | |||||||||||||||||||||||||||||||||||||
| Additional disclosures [Abstract] | ||||||||||||||||||||||||||||||||||||||
| Options outstanding, weighted average remaining contractual term | 7 years 4 months 24 days | |||||||||||||||||||||||||||||||||||||
| Options outstanding, aggregate intrinsic value | 1,500,000 | |||||||||||||||||||||||||||||||||||||
| Options exercisable, weighted average remaining contractual term | 6 years 6 months | |||||||||||||||||||||||||||||||||||||
| Options exercisable, aggregate intrinsic value | 800,000 | |||||||||||||||||||||||||||||||||||||
| Minimum age required for employees to qualify for immediate vesting of RSUs | 55 | |||||||||||||||||||||||||||||||||||||
| Threshold years required for retirement age | 70 years | |||||||||||||||||||||||||||||||||||||
| Unvested RSU activity [Roll Forward] | ||||||||||||||||||||||||||||||||||||||
| Unvested balance, beginning of period (in shares) | 903,874 | |||||||||||||||||||||||||||||||||||||
| Granted (in shares) | 1,292,923 | 1,177,082 | ||||||||||||||||||||||||||||||||||||
| Vested (in shares) | (590,862) | |||||||||||||||||||||||||||||||||||||
| Forfeited (in shares) | (212,055) | |||||||||||||||||||||||||||||||||||||
| Unvested balance, end of period (in shares) | 1,393,880 | 903,874 | ||||||||||||||||||||||||||||||||||||
| Unvested RSU activity, weighted average grant date fair value [Roll Forward] | ||||||||||||||||||||||||||||||||||||||
| Unvested balance, beginning of period (in dollars per share) | $ 1.69 | |||||||||||||||||||||||||||||||||||||
| Granted (in dollars per share) | $ 2.83 | |||||||||||||||||||||||||||||||||||||
| Vested (in dollars per share) | $ 2.27 | |||||||||||||||||||||||||||||||||||||
| Forfeited (in dollars per share) | $ 1.69 | |||||||||||||||||||||||||||||||||||||
| Unvested balance, end of period (in dollars per share) | $ 2.75 | $ 1.69 | ||||||||||||||||||||||||||||||||||||
| Total grant-date fair value of RSUs, vested | 1,300,000 | |||||||||||||||||||||||||||||||||||||
| Stock-based awards weighted average assumptions [Abstract] | ||||||||||||||||||||||||||||||||||||||
| Dividend yield (in hundredths) | 0.00% | 0.00% | 0.00% | |||||||||||||||||||||||||||||||||||
| Expected volatility (in hundredths) | 92.00% | 88.00% | 79.00% | |||||||||||||||||||||||||||||||||||
| Risk free interest rate (in hundredths) | 0.82% | 1.48% | 1.67% | |||||||||||||||||||||||||||||||||||
| Expected term | 5 years 7 months 6 days | 5 years 4 months 24 days | 5 years 3 months 18 days | |||||||||||||||||||||||||||||||||||
| Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] | ||||||||||||||||||||||||||||||||||||||
| Total stock-based compensation expense | 4,284,000 | 7,759,000 | 4,913,000 | 2,391,000 | 3,672,000 | 2,302,000 | 1,893,000 | 4,087,000 | 2,611,000 | 700,000 | ||||||||||||||||||||||||||||
| Capitalized stock-based compensation cost | 0 | 0 | ||||||||||||||||||||||||||||||||||||
| Tax benefits recognized related to stock-based compensation expense | $ 0 | $ 0 | ||||||||||||||||||||||||||||||||||||
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