Annual report pursuant to Section 13 and 15(d)

Commitments and Contingencies (Details)

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Commitments and Contingencies (Details) (USD $)
 12 Months Ended
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Apr. 08, 2011
Commitments and Contingencies [Abstract]        
Royalties paid, minimum (in hundredths) 1.50%      
Royalties paid, maximum (in hundredths) 14.00%      
Sublicense fees paid, maximum (in hundredths) 40.00%      
Estimate of milestone payments $ 96,000,000      
Estimated future minimum lease commitments [Abstract]        
2013 2,662,000 [1]      
2014 795,000 [1]      
Minimum lease payments 3,457,000 [1]      
Total rental expense 4,500,000 5,100,000 5,100,000  
Sublease income 100,000      
Future sublease income 900,000      
Sublease income receivable $ 200,000      
Number of buildings lease agreements of which renewed 3      
Renewed period of operating lease agreement 10 years      
Loss Contingencies [Line Items]        
Number of complaints filed       4
Number of cases dismissed 4      
Number of cases transferred to a different court 4      
[1] Operating leases are net of future sublease income of $0.9 million.