Annual report pursuant to Section 13 and 15(d)

Quarterly Financial Information (unaudited) (Details)

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Quarterly Financial Information (unaudited) (Details) (USD $)
 3 Months Ended 9 Months Ended 12 Months Ended
Dec. 31, 2012
Sep. 30, 2012
Jun. 30, 2012
Mar. 31, 2012
Dec. 31, 2011
Sep. 30, 2011
Jun. 30, 2011
Mar. 31, 2011
Sep. 30, 2011
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Quarterly Financial Information (unaudited) [Abstract]                        
Total revenues $ 7,391,000 $ 7,251,000 $ 9,275,000 $ 9,865,000 $ 9,847,000 [1] $ 16,229,000 [1] $ 16,525,000 [1] $ 15,595,000 [1]   $ 33,782,000 $ 58,196,000 $ 33,641,000
Total operating costs and expenses (19,834,000) (23,404,000) (22,765,000) (24,227,000) (21,894,000) (23,147,000) (24,394,000) (22,716,000)   (90,230,000) (92,151,000) (100,745,000)
Other income (expense), net 14,985,000 [2] (10,772,000) [2] (2,665,000) [2] (16,063,000) [2] 312,000 375,000 (261,000) 801,000        
Income tax expense 0 74,000 0 0 0 0 0 (15,000)   74,000 (15,000) (27,000)
Net income (loss) 2,542,000 (26,851,000) (16,155,000) (30,425,000) (11,735,000) (6,543,000) (8,130,000) (6,335,000)   (70,889,000) (32,743,000) (68,756,000)
Basic and diluted net loss (income) per share of common stock (in dollars per share) $ 0.03 $ (0.39) $ (0.24) $ (0.69) $ (0.34) $ (0.2) $ (0.27) $ (0.22)   $ (1.1) $ (1.04) $ (3.69)
Licensing fee, non-recurring                 $ 14,900,000      
[1] Revenue in the first three quarters of 2011 includes the recognition of $14.9 million of the non-recurring license fee received as consideration for the collaboration with Servier entered into in December 2010.
[2] Fluctuations in 2012 primarily relate to (losses) gains on the revaluation of the contingent warrant liabilities.