Quarterly report pursuant to Section 13 or 15(d)

Long-Term Debt and Other Financings - Novartis Note - Additional Information (Details)

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Long-Term Debt and Other Financings - Novartis Note - Additional Information (Details) - USD ($)
9 Months Ended
Sep. 30, 2015
Sep. 30, 2015
Dec. 31, 2014
Novartis Note [Member]      
Debt Instrument [Line Items]      
Maturity date   Jun. 30, 2015  
Research and development expenses funded through loan facility, maximum   75.00%  
Maximum borrowing capacity under loan agreement $ 50,000,000 $ 50,000,000  
Interest rate at period end 2.44% 2.44%  
Outstanding principal balance $ 13,500,000 $ 13,500,000 $ 13,400,000
Novartis Note [Member] | Six-month LIBOR [Member]      
Debt Instrument [Line Items]      
Basis spread on variable rate   2.00%  
Secured Note Amendment [Member]      
Debt Instrument [Line Items]      
Maturity date Sep. 30, 2020    
Reduction in outstanding principal amount $ 7,300,000