Quarterly report pursuant to Section 13 or 15(d)

Long-Term Debt and Other Financings - Interest Expense and Amortization of Debt Issuance Costs (Details)

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Long-Term Debt and Other Financings - Interest Expense and Amortization of Debt Issuance Costs (Details) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2015
Sep. 30, 2014
Sep. 30, 2015
Sep. 30, 2014
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense $ 1,030 $ 1,060 $ 3,152 $ 3,295
Hercules Loan [Member]        
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense 665   1,551  
Servier Loan [Member]        
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense 278 583 806 1,770
GECC Term Loan [Member]        
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense   398 548 1,268
Novartis Note [Member]        
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense 84 $ 79 243 234
Other [Member]        
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense $ 3   $ 4 $ 23