Quarterly report pursuant to Section 13 or 15(d)

Long-Term Debt and Other Financings - Servier Loan Agreement - Additional Information (Details)

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Long-Term Debt and Other Financings - Servier Loan Agreement - Additional Information (Details)
1 Months Ended 3 Months Ended 6 Months Ended 9 Months Ended 12 Months Ended 44 Months Ended
Jan. 09, 2015
USD ($)
Tranche
Jul. 31, 2015
USD ($)
Jan. 31, 2015
USD ($)
Jan. 31, 2011
USD ($)
Sep. 30, 2015
USD ($)
€ / $
Sep. 30, 2014
USD ($)
Jul. 31, 2015
Jul. 31, 2011
Sep. 30, 2015
USD ($)
€ / $
Sep. 30, 2014
USD ($)
Dec. 31, 2014
USD ($)
€ / $
Jan. 31, 2015
Sep. 30, 2015
EUR (€)
€ / $
Jan. 09, 2015
EUR (€)
Tranche
Debt Instrument [Line Items]                            
Accrued interest paid                 $ 1,452,000 $ 2,848,000        
Debt issuance costs                     $ 0      
Carrying value of the loan         $ 48,585,000       48,585,000          
Unrealized foreign exchange gain (loss)                 $ 1,344,000 1,541,000        
Servier Loan [Member]                            
Debt Instrument [Line Items]                            
Date of agreement                 Dec. 30, 2010          
Maximum borrowing capacity under loan agreement | €                         € 15,000,000  
Proceeds from loan       $ 19,500,000                    
Interest rate during period               3.22%            
Interest rates reset semi-annually, minimum                       2.31%    
Interest rates reset semi-annually, maximum                       3.83%    
Accrued interest paid   $ 200,000 $ 200,000                      
Date of loan amendment                 Jan. 09, 2015          
Date of agreement, after amendment                 Aug. 12, 2013          
Number of tranches | Tranche 3                         3
Debt issuance costs $ 6,000                          
Unamortized discount on debt $ 1,900,000       8,900,000       $ 8,900,000          
Amortization of debt discount         200,000 $ 500,000     500,000 1,400,000        
Carrying value of the loan         15,600,000       15,600,000   16,200,000      
Unrealized foreign exchange gain (loss) related to re-measurement of loan discount         17,000 (200,000)     $ (200,000) (200,000)        
Agreement termination date                 Sep. 28, 2015          
Agreement termination notice period                 180 days          
Outstanding principal balance         $ 16,900,000       $ 16,900,000   $ 18,200,000      
Euro to US Dollar exchange rates | € / $         1.124       1.124   1.216   1.124  
Unrealized foreign exchange gain (loss)         $ (200,000) $ 1,400,000     $ 1,400,000 $ 1,600,000        
Servier Loan [Member] | Tranche One [Member]                            
Debt Instrument [Line Items]                            
Maturity date Jan. 15, 2016                          
Principal payment amount | €                           € 3,000,000
Servier Loan [Member] | Tranche Two [Member]                            
Debt Instrument [Line Items]                            
Maturity date Jan. 15, 2017                          
Principal payment amount | €                           5,000,000
Servier Loan [Member] | Tranche Three [Member]                            
Debt Instrument [Line Items]                            
Maturity date Jan. 15, 2018                          
Principal payment amount | €                           € 7,000,000
Servier Loan [Member] | Mid-January 2015 Through Mid-July 2015 [Member]                            
Debt Instrument [Line Items]                            
Interest rate during period             2.16%              
Period of interest resetting                 6 months          
Servier Loan [Member] | Mid-July 2015 Through Mid-January 2016 [Member]                            
Debt Instrument [Line Items]                            
Interest rate during period                 2.05%          
Period of interest resetting                 6 months