Annual report pursuant to Section 13 and 15(d)

Fair Value Measurements - Outstanding Debt Carrying Amount and Estimated Fair Value (Details)

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Fair Value Measurements - Outstanding Debt Carrying Amount and Estimated Fair Value (Details) - USD ($)
$ in Thousands
Dec. 31, 2015
Dec. 31, 2014
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]    
Interest-bearing obligations, Carrying amount $ 48,667 $ 35,308
Interest bearing obligations, Fair value 49,810 36,461
Hercules Term Loan [Member]    
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]    
Interest-bearing obligations, Carrying amount 19,653  
Interest bearing obligations, Fair value 21,231  
Servier Loan [Member]    
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]    
Interest-bearing obligations, Carrying amount 15,331 16,290
Interest bearing obligations, Fair value 15,185 17,068
Novartis Note [Member]    
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]    
Interest-bearing obligations, Carrying amount 13,683 13,357
Interest bearing obligations, Fair value $ 13,394 12,923
General Electric Capital Corporation Term Loan [Member]    
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]    
Interest-bearing obligations, Carrying amount   5,661
Interest bearing obligations, Fair value   $ 6,470