Annual report pursuant to Section 13 and 15(d)

Long-Term Debt and Other Financings - Interest Expense and Amortization of Debt Issuance Costs (Details)

v3.3.1.900
Long-Term Debt and Other Financings - Interest Expense and Amortization of Debt Issuance Costs (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Interest expense and amortization of debt issuance costs [Abstract]      
Interest expense $ 4,194 $ 4,303 $ 4,631
Hercules Loan [Member]      
Interest expense and amortization of debt issuance costs [Abstract]      
Interest expense 2,223    
Servier Loan [Member]      
Interest expense and amortization of debt issuance costs [Abstract]      
Interest expense 1,083 2,330 2,152
GECC Term Loan [Member]      
Interest expense and amortization of debt issuance costs [Abstract]      
Interest expense 548 1,638 2,064
Novartis Note [Member]      
Interest expense and amortization of debt issuance costs [Abstract]      
Interest expense 329 312 362
Other [Member]      
Interest expense and amortization of debt issuance costs [Abstract]      
Interest expense $ 11 $ 23 $ 53