Annual report pursuant to Section 13 and 15(d)

Long-Term Debt and Other Financings - Servier Loan Agreement - Additional Information (Details)

v3.3.1.900
Long-Term Debt and Other Financings - Servier Loan Agreement - Additional Information (Details)
$ in Thousands
 1 Months Ended 6 Months Ended 12 Months Ended 44 Months Ended
Jan. 09, 2015
USD ($)
Tranche
Jan. 31, 2016
USD ($)
Jan. 31, 2011
USD ($)
Jul. 31, 2015
Jul. 31, 2011
Dec. 31, 2015
USD ($)
€ / $
Dec. 31, 2014
USD ($)
€ / $
Dec. 31, 2013
USD ($)
Jan. 31, 2015
Dec. 31, 2015
EUR (€)
€ / $
Jan. 09, 2015
EUR (€)
Tranche
Debt Instrument [Line Items]                      
Accrued interest paid           $ 1,927 $ 3,009 $ 1,262      
Carrying value of the loan           48,667 35,308        
Unrealized foreign exchange gain (loss)           $ 1,870 2,280 (662)      
Servier Loan [Member]                      
Debt Instrument [Line Items]                      
Date of agreement           Dec. 30, 2010          
Maximum borrowing capacity under loan agreement | €                   € 15,000,000  
Proceeds from loan     $ 19,500                
Interest rate during period         3.22%            
Interest rates reset semi-annually, minimum                 2.05%    
Interest rates reset semi-annually, maximum                 3.83%    
Date of loan amendment           Jan. 09, 2015          
Date of agreement, after amendment           Aug. 12, 2013          
Number of tranches | Tranche 3                   3
Unamortized discount on debt $ 1,900   $ 8,900                
Amortization of debt discount           $ 700 1,900 1,600      
Carrying value of the loan           15,300 16,200        
Unrealized foreign exchange gain (loss) related to re-measurement of loan discount           $ (200) (300) 200      
Agreement termination date           Sep. 28, 2015          
Agreement termination notice period           180 days          
Outstanding principal balance           $ 16,400 $ 18,200        
Euro to US Dollar exchange rates | € / $           1.091 1.216     1.091  
Unrealized foreign exchange gain (loss)           $ 1,900 $ 2,400 $ (800)      
Servier Loan [Member] | Tranche One [Member]                      
Debt Instrument [Line Items]                      
Maturity date Jan. 15, 2016                    
Principal payment amount | €                     € 3,000,000
Servier Loan [Member] | Tranche Two [Member]                      
Debt Instrument [Line Items]                      
Maturity date Jan. 15, 2017                    
Principal payment amount | €                     5,000,000
Servier Loan [Member] | Tranche Three [Member]                      
Debt Instrument [Line Items]                      
Maturity date Jan. 15, 2018                    
Principal payment amount | €                     € 7,000,000
Servier Loan [Member] | Subsequent Event                      
Debt Instrument [Line Items]                      
Accrued interest paid   $ 200                  
Servier Loan [Member] | Mid-January 2015 Through Mid-July 2015 [Member]                      
Debt Instrument [Line Items]                      
Interest rate during period       2.16%              
Period of interest resetting           6 months          
Servier Loan [Member] | Mid-July 2015 Through Mid-January 2016 [Member]                      
Debt Instrument [Line Items]                      
Interest rate during period           2.05%          
Period of interest resetting           6 months