Annual report pursuant to Section 13 and 15(d)

Commitments and Contingencies - Additional Information (Details)

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Commitments and Contingencies - Additional Information (Details)
 1 Months Ended 12 Months Ended
Dec. 31, 2018
USD ($)
Facility
Apr. 14, 2018
USD ($)
Facility
Nov. 21, 2017
USD ($)
Facility
Oct. 31, 2018
USD ($)
Facility
Sep. 30, 2017
Dec. 31, 2018
USD ($)
Facility
Dec. 31, 2017
USD ($)
Commitments And Contingencies [Line Items]              
Estimate of milestone payments $ 7,500,000         $ 7,500,000  
Operating leases, expiry date           2023-04  
Operating leases, number of leased facilities | Facility   3 3 3      
Total lease payments 14,925,000         $ 14,925,000  
Operating leases, total rental expense           2,100,000 $ 2,400,000
Operating leases, number of portions of leased facilities | Facility   1 1 1      
Operating leases, sublease commencement date   May 01, 2018 Dec. 26, 2017 Oct. 24, 2018      
Operating leases sublease income plus reimbursement of operating expenses receivable   $ 1,100,000 $ 5,100,000        
Operating leases sublease expiry date   2023-04 2023-04 2021-05      
Sublease tenant improvement allowance   $ 65,000 $ 800,000        
Operating leases sublease income receivable       $ 1,700,000      
Llease Agreement Commenced in Septembr 2017 [Member]              
Commitments And Contingencies [Line Items]              
Lease agreement term         63 months    
Lease commencement date         Nov. 14, 2017    
Total lease payments 800,000         $ 800,000  
Lease payments term         2023-02    
Sublease Agreement Commenced on December 26, 2017 [Member]              
Commitments And Contingencies [Line Items]              
Sublease loss     800,000        
Sublease income     1,500,000        
Sublease Agreement Commenced on December 26, 2017 [Member] | Standby Letter of Credit [Member]              
Commitments And Contingencies [Line Items]              
Letter of credit amount     $ 1,000,000        
Funds drawn from letter of credit $ 0            
Sublease Agreement Commenced on May 1,2018 [Member]              
Commitments And Contingencies [Line Items]              
Sublease income   300,000          
Sublease broker commissions   89,000          
Sublease Agreement Commenced on May 1,2018 [Member] | Restructuring Charges [Member]              
Commitments And Contingencies [Line Items]              
Sublease loss   $ 600,000          
Sublease Agreement Commenced on October 24,2018 [Member]              
Commitments And Contingencies [Line Items]              
Sublease loss       0      
Sublease broker commissions       $ 137,000      
Berkeley, California [Member]              
Commitments And Contingencies [Line Items]              
Operating leases, number of leased facilities | Facility 2         2