Annual report pursuant to Section 13 and 15(d)

CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS

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CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS (USD $)
In Thousands, except Per Share data, unless otherwise specified
 12 Months Ended
Dec. 31, 2013
Dec. 31, 2012
Dec. 31, 2011
Revenues:      
License and collaborative fees $ 11,028 $ 5,727 $ 17,991
Contract and other 24,423 28,055 40,205
Total revenues 35,451 33,782 58,196
Operating expenses:      
Research and development 74,851 68,467 68,137
Selling, general and administrative 18,477 16,865 24,014
Restructuring 328 5,074 0
Total operating expenses 93,656 90,406 92,151
Loss from operations (58,205) (56,624) (33,955)
Other (expense) income:      
Interest expense (4,631) (4,387) (2,462)
Other expense (197) (956) (177)
Revaluation of contingent warrant liabilities (61,039) (9,172) 3,866
Net loss before taxes (124,072) (71,139) (32,728)
Provision for income tax benefit (expense) 14 74 (15)
Net loss (124,058) (71,065) (32,743)
Basic and diluted net loss per share of common stock (in dollars per share) $ (1.43) $ (1.10) $ (1.04)
Shares used in computing basic and diluted net loss per share of common stock (in shares) 86,938 64,629 31,590
Comprehensive loss:      
Net loss (124,058) (71,065) (32,743)
Net unrealized (loss) gains on available-for-sale securities (9) 8 0
Comprehensive loss $ (124,067) $ (71,057) $ (32,743)