Quarterly report pursuant to Section 13 or 15(d)

Long-Term Debt - Servier Loan Agreement - Additional Information (Details)

v3.5.0.2
Long-Term Debt - Servier Loan Agreement - Additional Information (Details)
1 Months Ended 3 Months Ended 6 Months Ended 9 Months Ended
Jan. 09, 2015
USD ($)
Tranche
Jan. 31, 2016
EUR (€)
Jan. 31, 2011
USD ($)
Sep. 30, 2016
USD ($)
€ / $
Sep. 30, 2015
USD ($)
Jan. 31, 2017
Jul. 31, 2016
Jan. 31, 2016
EUR (€)
Jul. 31, 2011
Sep. 30, 2016
USD ($)
€ / $
Sep. 30, 2015
USD ($)
Sep. 30, 2016
EUR (€)
€ / $
Dec. 31, 2015
USD ($)
€ / $
Jan. 09, 2015
EUR (€)
Tranche
Debt Instrument [Line Items]                            
Accrued interest paid                   $ 1,724,000 $ 1,452,000      
Carrying value of the loan       $ 45,219,000           $ 45,219,000     $ 48,667,000  
Servier Loan [Member]                            
Debt Instrument [Line Items]                            
Date of agreement                   Dec. 30, 2010        
Maximum borrowing capacity under loan agreement | €                       € 15,000,000    
Proceeds from loan     $ 19,500,000                      
Interest rate during period                 3.22%          
Date of loan amendment                   Jan. 09, 2015        
Date of agreement, after amendment                   Aug. 12, 2013        
Number of tranches | Tranche 3                         3
Principal payment amount | €   € 3,000,000           € 3,000,000            
Accrued interest paid | €   € 200,000                        
Unamortized discount on debt $ 1,900,000   $ 8,900,000                      
Amortization of debt discount       200,000 $ 200,000         $ 500,000 500,000      
Carrying value of the loan       12,900,000           12,900,000     15,300,000  
Unrealized foreign exchange gains (loss) related to re-measurement of loan discount       6,000 17,000         $ 26,000 (200,000)      
Agreement termination date                   Sep. 28, 2015        
Agreement termination notice period                   180 days        
Outstanding principal balance       $ 13,500,000           $ 13,500,000     $ 16,400,000  
Euro to US Dollar exchange rates | € / $       1.121           1.121   1.121 1.091  
Unrealized foreign exchange gains (loss) related to re-measurement of loan       $ (100,000) $ (200,000)         $ (400,000) $ 1,400,000      
Servier Loan [Member] | Tranche One [Member]                            
Debt Instrument [Line Items]                            
Maturity date Jan. 15, 2016                          
Principal payment amount | €                           € 3,000,000
Servier Loan [Member] | Tranche Two [Member]                            
Debt Instrument [Line Items]                            
Maturity date Jan. 15, 2017                          
Principal payment amount | €                           5,000,000
Servier Loan [Member] | Tranche Three [Member]                            
Debt Instrument [Line Items]                            
Maturity date Jan. 15, 2018                          
Principal payment amount | €                           € 7,000,000
Servier Loan [Member] | Minimum [Member]                            
Debt Instrument [Line Items]                            
Interest rates reset semi-annually       1.81%           1.81%   1.81%    
Servier Loan [Member] | Maximum [Member]                            
Debt Instrument [Line Items]                            
Interest rates reset semi-annually       3.83%           3.83%   3.83%    
Servier Loan [Member] | Mid-July 2015 Through Mid-January 2016 [Member]                            
Debt Instrument [Line Items]                            
Interest rate during period               2.05%            
Period of interest resetting               6 months            
Servier Loan [Member] | Mid-January 2016 Through Mid-July 2016 [Member]                            
Debt Instrument [Line Items]                            
Interest rate during period             1.95%              
Period of interest resetting             6 months              
Servier Loan [Member] | Scenario, Forecast [Member] | Mid-July 2016 Through Mid-January 2017 [Member]                            
Debt Instrument [Line Items]                            
Interest rate during period           1.81%                
Period of interest resetting           6 months