Quarterly report pursuant to Section 13 or 15(d)

Stock-based Compensation - Stock-based Compensation Expense (Details)

v3.5.0.2
Stock-based Compensation - Stock-based Compensation Expense (Details) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2016
Sep. 30, 2015
Sep. 30, 2016
Sep. 30, 2015
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]        
Total stock-based compensation expense $ 1,729 $ 1,964 $ 6,200 $ 8,318
Research and Development [Member]        
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]        
Total stock-based compensation expense 802 1,047 2,796 4,642
Selling, General and Administrative [Member]        
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]        
Total stock-based compensation expense $ 927 $ 917 $ 3,404 $ 3,676