Quarterly report pursuant to Section 13 or 15(d)

Long-Term Debt - Interest Expense and Amortization of Debt Issuance Costs (Details)

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Long-Term Debt - Interest Expense and Amortization of Debt Issuance Costs (Details) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2016
Sep. 30, 2015
Sep. 30, 2016
Sep. 30, 2015
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense $ 982 $ 1,030 $ 2,991 $ 3,152
Hercules Term Loan [Member]        
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense 651 665 2,001 1,551
Servier Loan [Member]        
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense 223 278 674 806
GECC Term Loan [Member]        
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense       548
Novartis Note [Member]        
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense 104 84 299 243
Other [Member]        
Interest expense and amortization of debt issuance costs [Abstract]        
Interest expense $ 4 $ 3 $ 17 $ 4