Quarterly report pursuant to Section 13 or 15(d)

Long-Term Debt - Interest Expense and Amortization of Debt Issuance Costs (Details)

v3.7.0.1
Long-Term Debt - Interest Expense and Amortization of Debt Issuance Costs (Details) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2017
Mar. 31, 2016
Interest expense and amortization of debt issuance costs [Abstract]    
Interest expense $ 609 $ 1,002
Hercules Term Loan [Member]    
Interest expense and amortization of debt issuance costs [Abstract]    
Interest expense 311 672
Servier Loan [Member]    
Interest expense and amortization of debt issuance costs [Abstract]    
Interest expense 177 226
Novartis Note [Member]    
Interest expense and amortization of debt issuance costs [Abstract]    
Interest expense 117 97
Other [Member]    
Interest expense and amortization of debt issuance costs [Abstract]    
Interest expense $ 4 $ 7