Quarterly report pursuant to Section 13 or 15(d)

Common Stock Warrants - Summary of Common Stock Warrants Outstanding (Details)

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Common Stock Warrants - Summary of Common Stock Warrants Outstanding (Details) - $ / shares
 3 Months Ended
Mar. 31, 2017
Dec. 31, 2016
Class Of Warrant Or Right [Line Items]    
Warrant outstanding (in shares) 19,279 498,556
Five Year Warrants Issued in March 2012 [Member]    
Class Of Warrant Or Right [Line Items]    
Exercise price of warrants (in dollars per share) $ 35.20  
Five Year Warrants Issued in March 2012 [Member] | Contingent Warrant Liability [Member]    
Class Of Warrant Or Right [Line Items]    
Issuance Date 2012-03  
Expiration Date 2017-03  
Exercise price of warrants (in dollars per share) $ 35.20  
Warrant outstanding (in shares)   479,277
Five Year Warrants Issued in September 2012 [Member] | Stockholders' Deficit [Member]    
Class Of Warrant Or Right [Line Items]    
Issuance Date 2012-09  
Expiration Date 2017-09  
Exercise price of warrants (in dollars per share) $ 70.80  
Warrant outstanding (in shares) 1,967 1,967
Five Year Warrants Issued in February 2015 [Member] | Stockholders' Deficit [Member]    
Class Of Warrant Or Right [Line Items]    
Issuance Date 2015-02  
Expiration Date 2020-02  
Exercise price of warrants (in dollars per share) $ 66.20  
Warrant outstanding (in shares) 9,063 9,063
Five Year Warrants Issued in February 2016 [Member] | Stockholders' Deficit [Member]    
Class Of Warrant Or Right [Line Items]    
Issuance Date 2016-02  
Expiration Date 2021-02  
Exercise price of warrants (in dollars per share) $ 15.40  
Warrant outstanding (in shares) 8,249 8,249