Annual report pursuant to Section 13 and 15(d)

Long-Term Debt and Other Financings - Servier Loan Agreement - Additional Information (Details)

v3.6.0.2
Long-Term Debt and Other Financings - Servier Loan Agreement - Additional Information (Details)
 1 Months Ended 6 Months Ended 12 Months Ended
Jan. 09, 2015
USD ($)
Tranche
Jan. 31, 2017
EUR (€)
Jan. 31, 2016
EUR (€)
Jan. 31, 2011
USD ($)
Jan. 31, 2017
EUR (€)
Dec. 31, 2016
USD ($)
€ / $
Dec. 31, 2015
USD ($)
€ / $
Dec. 31, 2014
USD ($)
Dec. 31, 2016
EUR (€)
€ / $
Jan. 09, 2015
EUR (€)
Tranche
Debt Instrument [Line Items]                    
Accrued interest paid           $ 2,142,000 $ 1,927,000 $ 3,009,000    
Carrying value of the loan           $ 43,167,000 48,667,000      
Subsequent Event [Member]                    
Debt Instrument [Line Items]                    
Maturity date   Jul. 15, 2017                
Servier Loan [Member]                    
Debt Instrument [Line Items]                    
Date of agreement           Dec. 30, 2010        
Maximum borrowing capacity under loan agreement | €                 € 15,000,000  
Proceeds from loan       $ 19,500,000            
Date of loan amendment           Jan. 09, 2015        
Date of agreement, after amendment           Aug. 12, 2013        
Number of tranches | Tranche 3                 3
Principal payment amount | €     € 3,000,000              
Accrued interest paid | €     € 200,000              
Unamortized discount on debt $ 1,900,000     $ 8,900,000            
Amortization of debt discount           $ 600,000 700,000 1,900,000    
Carrying value of the loan           12,231,000 15,331,000      
Unrealized foreign exchange gain (losses) related to re-measurement of loan discount           $ 5,000 (200,000) (300,000)    
Agreement termination date           Sep. 28, 2015        
Agreement termination notice period           180 days        
Outstanding principal balance           $ 12,600,000 $ 16,400,000      
Euro to US Dollar exchange rates | € / $           1.052 1.091   1.052  
Unrealized foreign exchange gains (loss) related to re-measurement of loan           $ 500,000 $ 1,900,000 $ 2,400,000    
Servier Loan [Member] | Tranche One [Member]                    
Debt Instrument [Line Items]                    
Maturity date Jan. 15, 2016                  
Principal payment amount | €                   € 3,000,000
Servier Loan [Member] | Tranche Two [Member]                    
Debt Instrument [Line Items]                    
Maturity date Jan. 15, 2017                  
Principal payment amount | €                   5,000,000
Servier Loan [Member] | Tranche Three [Member]                    
Debt Instrument [Line Items]                    
Maturity date Jan. 15, 2018                  
Principal payment amount | €                   € 7,000,000
Servier Loan [Member] | Subsequent Event [Member] | Mid-July 2016 Through Mid-January 2017 [Member]                    
Debt Instrument [Line Items]                    
Period of interest resetting         6 months          
Interest rate during period         1.81%          
Servier Loan [Member] | Subsequent Event [Member] | Amendment No.3 [Member] | Tranche Two [Member]                    
Debt Instrument [Line Items]                    
Maturity date   Jul. 15, 2017                
Principal payment amount | €   € 5,000,000     € 5,000,000